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Acclimatisation (neurones)
Acclimatisation is the process by which the nervous system fails to respond to a stimulus, as a result of the repeated stimulation of a transmission across a synapse. Acclimatisation is believed to occur when the synaptic knob of the presynaptic neuron runs out of vesicles containing neurotransmitters due to overuse over a short period of time. A synapse that has undergone acclimatisation is said to be fatigued. ''Hocking, S,'' et al, (2008), ''OCR Biology A2'', Harlow: Heinemann, pg. 20 Acclimatisation is said to be responsible for 'getting used to' background noises and smells. See also * Adaptive system * Neural adaptation Neural adaptation or sensory adaptation is a gradual decrease over time in the responsiveness of the sensory system to a constant stimulus. It is usually experienced as a change in the stimulus. For example, if a hand is rested on a table, the tabl ... References Cellular neuroscience {{neuroscience-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Synaptic Knob
Chemical synapses are biological junctions through which neurons' signals can be sent to each other and to non-neuronal cells such as those in muscles or glands. Chemical synapses allow neurons to form circuits within the central nervous system. They are crucial to the biological computations that underlie perception and thought. They allow the nervous system to connect to and control other systems of the body. At a chemical synapse, one neuron releases neurotransmitter molecules into a small space (the synaptic cleft) that is adjacent to another neuron. The neurotransmitters are contained within small sacs called synaptic vesicles, and are released into the synaptic cleft by exocytosis. These molecules then bind to neurotransmitter receptors on the postsynaptic cell. Finally, the neurotransmitters are cleared from the synapse through one of several potential mechanisms including enzymatic degradation or re-uptake by specific transporters either on the presynaptic cell or on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neuron
A neuron, neurone, or nerve cell is an electrically excitable cell that communicates with other cells via specialized connections called synapses. The neuron is the main component of nervous tissue in all animals except sponges and placozoa. Non-animals like plants and fungi do not have nerve cells. Neurons are typically classified into three types based on their function. Sensory neurons respond to stimuli such as touch, sound, or light that affect the cells of the sensory organs, and they send signals to the spinal cord or brain. Motor neurons receive signals from the brain and spinal cord to control everything from muscle contractions to glandular output. Interneurons connect neurons to other neurons within the same region of the brain or spinal cord. When multiple neurons are connected together, they form what is called a neural circuit. A typical neuron consists of a cell body (soma), dendrites, and a single axon. The soma is a compact structure, and the axon and dend ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Presynaptic Vesicle
In a neuron, synaptic vesicles (or neurotransmitter vesicles) store various neurotransmitters that are released at the synapse. The release is regulated by a voltage-dependent calcium channel. Vesicles are essential for propagating nerve impulses between neurons and are constantly recreated by the cell. The area in the axon that holds groups of vesicles is an axon terminal or "terminal bouton". Up to 130 vesicles can be released per bouton over a ten-minute period of stimulation at 0.2 Hz. In the visual cortex of the human brain, synaptic vesicles have an average diameter of 39.5 nanometers (nm) with a standard deviation of 5.1 nm. Structure Synaptic vesicles are relatively simple because only a limited number of proteins fit into a sphere of 40 nm diameter. Purified vesicles have a protein:phospholipid ratio of 1:3 with a lipid composition of 40% phosphatidylcholine, 32% phosphatidylethanolamine, 12% phosphatidylserine, 5% phosphatidylinositol, and 10% chole ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neurotransmitters
A neurotransmitter is a signaling molecule secreted by a neuron to affect another cell across a synapse. The cell receiving the signal, any main body part or target cell, may be another neuron, but could also be a gland or muscle cell. Neurotransmitters are released from synaptic vesicles into the synaptic cleft where they are able to interact with neurotransmitter receptors on the target cell. The neurotransmitter's effect on the target cell is determined by the receptor it binds. Many neurotransmitters are synthesized from simple and plentiful precursors such as amino acids, which are readily available and often require a small number of biosynthetic steps for conversion. Neurotransmitters are essential to the function of complex neural systems. The exact number of unique neurotransmitters in humans is unknown, but more than 100 have been identified. Common neurotransmitters include glutamate, GABA, acetylcholine, glycine and norepinephrine. Mechanism and cycle Synthe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Synaptic Fatigue
Synaptic fatigue, or short-term synaptic depression, is an activity-dependent form of short term synaptic plasticity that results in the temporary inability of neurons to fire and therefore transmit an input signal. It is thought to be a form of negative feedback in order to physiologically control particular forms of nervous system activity.Kilpatrick, Z. P. (2010). Spatially Structured Waves and Oscillations in Neuronal Networks With Synaptic Depression and Adaptation. Doctor of Philosophy, University of Utah. It is caused by a temporary depletion of synaptic vesicles that house neurotransmitters in the synapse, generally produced by persistent high frequency neuronal stimulation. The neurotransmitters are released by the synapse to propagate the signal to the postsynaptic cell. It has also been hypothesized that synaptic fatigue could be a result of postsynaptic receptor desensitization or changes in postsynaptic passive conductance, but recent evidence has suggested that it ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adaptive System
An adaptive system is a set of interacting or interdependent entities, real or abstract, forming an integrated whole that together are able to respond to environmental changes or changes in the interacting parts, in a way analogous to either continuous physiological homeostasis or evolutionary adaptation in biology. Feedback loops represent a key feature of adaptive systems, such as ecosystems and individual organisms; or in the human world, communities, organizations, and families. Adaptive systems can be organized into a hierarchy. Artificial adaptive systems include robots with control systems that utilize negative feedback to maintain desired states. The law of adaptation The law of adaptation may be stated informally as: Formally, the law can be defined as follows: Given a system S, we say that a physical event E is a stimulus for the system S if and only if the probability P(S \rightarrow S', E) that the system suffers a change or be perturbed (in its elements or i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neural Adaptation
Neural adaptation or sensory adaptation is a gradual decrease over time in the responsiveness of the sensory system to a constant stimulus. It is usually experienced as a change in the stimulus. For example, if a hand is rested on a table, the table's surface is immediately felt against the skin. Subsequently, however, the sensation of the table surface against the skin gradually diminishes until it is virtually unnoticeable. The sensory neurons that initially respond are no longer stimulated to respond; this is an example of neural adaptation. All sensory and neural systems have a form of adaptation to constantly detect changes in the environment. Neural receptor cells that process and receive stimulation go through constant changes for mammals and other living organisms to sense vital changes in their environment. Some key players in several neural systems include Ca2+ions (see Calcium in biology) that send negative feedback in second messenger pathways that allow the neural recep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
