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ARC3 Family
The arsenical resistance-3 (ACR3) familyTC# 2.A.59 is a member of the BART superfamily. Based on operon analyses, ARC3 homologues may function either as secondary carriers or as primary active transporters, similarly to the ArsB and ArsAB families. In the latter case ATP hydrolysis again energizes transport. ARC3 homologues transport the same anions as ArsA/AB homologues, though ArsB homologues are members of the IT Superfamily and homologues of the ARC3 family are within the BART Superfamily suggesting they may not be evolutionarily related. Structure and Homology ''Bacillus'' ARC3 (ArsBTC# 2.A.59.1.2 probably has a 10 TMS topology. ACR3 of ''S. cerevisiae'' is 404 amino acyl residues long and exhibits 10 putative transmembrane α-helical spanners (TMSs). Homologues are found in ''Mycobacterium tuberculosis'' (498 aas; gbZ80225), ''Archaeoglobus fulgidus'' (370 aas; gbAE001071), '' Methanobacterium thermoautotrophicum'' (365 aas; gbAE000865) and ''Synechocystis'' (383 aas; sp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BART Superfamily
The Bile/Arsenite/Riboflavin Transporter (BART) superfamily is a superfamily SUPERFAMILY is a database and search platform of structural and functional annotation for all proteins and genomes. It classifies amino acid sequences into known structural domains, especially into SCOP superfamilies. Domains are functional, str ... of ubiquitous transport proteins. As of early 2016, the superfamily contains seven established families.Mansour, N.M., Sawhney, M., Tamang, D.G., Vogl, C., Saier, M.H. Jr. 2007. The bile-arsenite-riboflavin transporter (BART) superfamily FEBS Journal 274(3):612-29. Functional data for members of all of these families are available. The seven families are in the Transporter Classification Database with the following TC numbers, names and abbreviations include: *TC# 2.A.10- The 2-Keto-3-Deoxygluconate Transporter (KdgT) Family *TC# 2.A.28- The Bile Acid:Na+ Symporter (BASS) Family *TC# 2.A.59- The Arsenical Resistance-3 (ACR3) Family *TC# 2.A.69- The Auxin Ef ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ArsB And ArsAB Family
Arsenite resistance (Ars) efflux pumps of bacteria may consist of two proteins, ArsBTC# 2.A.45.1.1 the integral membrane constituent with twelve transmembrane spanners) and ArsATC# 3.A.4.1.1 the ATP-hydrolyzing, transport energizing subunit, as for the chromosomally-encoded ''E. coli'' system), or of one protein (just the ArsB integral membrane protein of the plasmid-encoded ''Staphylococcus'' system). ArsA proteins have two ATP binding domains and probably arose by a tandem gene duplication event. ArsB proteins all possess twelve transmembrane spanners and may also have arisen by a tandem gene duplication event. Structurally, the Ars pumps resemble ABC-type efflux pumps, but there is no significant sequence similarity between the Ars and ABC pumps. When only ArsB is present, the system operates by a pmf-dependent mechanism, and consequently belongs in TC subclass 2.A (i.eTC# 2.A.45. When ArsA is also present, ATP hydrolysis drives efflux, and consequently the system belongs in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ion Transporter Superfamily
The ion transporter (IT) superfamily is a protein superfamily, superfamily of secondary carriers that transport proteins, transport charged substrates. Families As of early 2016, the currently recognized and functionally defined families that make up the IT superfamily include: 2.A.8- Gluconate-Proton symporter, The Gluconate:H+ Symporter (GntP) Family 2.A.11- Citrate symporter, The Citrate-Mg2+:H+ (CitM) Citrate-Ca2+:H+ (CitH) Symporter (CitMHS) Family 2.A.13- C4-dicarboxylate uptake, The C4-Dicarboxylate Uptake (Dcu) Family 2.A.14- Lactate permease, The Lactate Permease (LctP) Family 2.A.34- NhaB family, The NhaB Na+:H+ Antiporter (NhaB) Family 2.A.35- NhaC family, The NhaC Na+:H+ Antiporter (NhaC) Family 2.A.45- ArsB and ArsAB transporters, The Arsenite-Antimonite (ArsB) Efflux Family 2.A.47- Divalent anion-Sodium symporter, The Divalent Anion:Na+ Symporter (DASS) Family 2.A.61- DcuC family, The C4-dicarboxylate Uptake C (DcuC) Family 2.A.62- NhaD family, The NhaD Na+:H+ Anti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mycobacterium Tuberculosis
''Mycobacterium tuberculosis'' (M. tb) is a species of pathogenic bacteria in the family Mycobacteriaceae and the causative agent of tuberculosis. First discovered in 1882 by Robert Koch, ''M. tuberculosis'' has an unusual, waxy coating on its cell surface primarily due to the presence of mycolic acid. This coating makes the cells impervious to Gram staining, and as a result, ''M. tuberculosis'' can appear weakly Gram-positive. Acid-fastness, Acid-fast stains such as Ziehl–Neelsen stain, Ziehl–Neelsen, or Fluorescence, fluorescent stains such as Auramine O, auramine are used instead to identify ''M. tuberculosis'' with a microscope. The physiology of ''M. tuberculosis'' is highly aerobic organism, aerobic and requires high levels of oxygen. Primarily a pathogen of the mammalian respiratory system, it infects the lungs. The most frequently used diagnostic methods for tuberculosis are the Mantoux test, tuberculin skin test, Acid-Fast Stain, acid-fast stain, Microbiological cultu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Archaeoglobus Fulgidus
''Archaeoglobus'' is a genus of the phylum Euryarchaeota. ''Archaeoglobus'' can be found in high-temperature oil fields where they may contribute to oil field souring. Metabolism ''Archaeoglobus'' grow anaerobically at extremely high temperatures between 60 and 95 °C, with optimal growth at 83 °C (ssp. ''A. fulgidus'' VC-16). They are sulfate-reducing archaea, coupling the reduction of sulfate to sulfide with the oxidation of many different organic carbon sources, including complex polymers. ''A. lithotrophicus'' live chemolitho-autotrophically from hydrogen, sulfate and carbon dioxide. Also ''A. profundus'' grow lithotrophically, but while this species needs acetate and CO2 for biosynthesis they are heterotroph. The complete ''A. fulgidus'' genome sequence revealed the presence of a nearly complete set of genes for methanogenesis. The function of these genes in ''A. fulgidus'' remains unknown, while the lack of the enzyme methyl-CoM reductase does not allow for ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Methanobacterium Thermoautotrophicum
In taxonomy, ''Methanobacterium'' is a genus of the Methanobacteriaceae family of Archaea.See the NCBIbr>webpage on Methanobacterium Data extracted from the Despite the name, this genus belongs not to the bacterial domain but the archaeal domain (for instance, they lack peptidoglycan in their cell walls). Methanobacterium are nonmotile and live without oxygen. Some members of this genus can use formate to reduce methane; others live exclusively through the reduction of carbon dioxide with hydrogen. They are ubiquitous in some hot, low-oxygen environments, such as anaerobic digestors, their wastewater, and hot springs. Examples of Methanobacterium Species ''Methanobacterium bryantii'' is part of the syntrophic ''Methanobacillus omelianskii'' culture. ''Methanobacterium thermoautotrophicum'' Marburg can undergo natural genetic transformation, the transfer of DNA from one cell to another. Genetic transformation in archaeal species, generally, appears to be an adaptation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Synechocystis
''Synechocystis'' is a genus of unicellular, freshwater cyanobacteria in the family Merismopediaceae. It includes a strain, ''Synechocystis'' sp. PCC 6803, which is a well studied model organism. Like all cyanobacteria, ''Synechocystis'' branches on the evolutionary tree from its ancestral root, ''Gloeobacter violaceus''. ''Synechocystis'' is not diazotrophic, and is closely related to another model organism, ''Cyanothece ''Cyanothece'' is a genus of unicellular, diazotrophic, oxygenic photosynthesizing cyanobacteria. Modern organisms and cellular organization In 1976, Jiří Komárek defined the prokaryotic cyanobacteria genus ''Cyanothece'' as distinct from ' ...'' ATCC 51442. It has been suggested that originally ''Synechocystis'' possessed the ability to fix atmospheric nitrogen, but lost the genes required for the process. See also * ''Synechocystis'' run-and-tumble References {{Taxonbar, from=Q7662346 Cyanobacteria genera Synechococcales Bacteria genera< ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Saccharomyces Cerevisiae
''Saccharomyces cerevisiae'' () (brewer's yeast or baker's yeast) is a species of yeast (single-celled fungus microorganisms). The species has been instrumental in winemaking, baking, and brewing since ancient times. It is believed to have been originally isolated from the skin of grapes. It is one of the most intensively studied eukaryotic model organisms in molecular biology, molecular and cell biology, much like ''Escherichia coli'' as the model bacteria, bacterium. It is the microorganism behind the most common type of fermentation (biochemistry), fermentation. ''S. cerevisiae'' cells are round to ovoid, 5–10 micrometre, μm in diameter. It reproduces by budding. Many proteins important in human biology were first discovered by studying their Homology (biology), homologs in yeast; these proteins include cell cycle proteins, signaling proteins, and protein-processing enzymes. ''S. cerevisiae'' is currently the only yeast cell known to have Berkeley body, Berkeley bo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bacillus Subtilis
''Bacillus subtilis'', known also as the hay bacillus or grass bacillus, is a Gram-positive, catalase-positive bacterium, found in soil and the gastrointestinal tract of ruminants, humans and marine sponges. As a member of the genus ''Bacillus'', ''B. subtilis'' is rod-shaped, and can form a tough, protective endospore, allowing it to tolerate extreme environmental conditions. ''B. subtilis'' has historically been classified as an obligate aerobe, though evidence exists that it is a facultative anaerobe. ''B. subtilis'' is considered the best studied Gram-positive bacterium and a model organism to study bacterial chromosome replication and cell differentiation. It is one of the bacterial champions in secreted enzyme production and used on an industrial scale by biotechnology companies. Description ''Bacillus subtilis'' is a Gram-positive bacterium, rod-shaped and catalase-positive. It was originally named ''Vibrio subtilis'' by Christian Gottfried Ehrenberg, and renamed ''B ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arsenite
In chemistry, an arsenite is a chemical compound containing an arsenic oxyanion where arsenic has oxidation state +3. Note that in fields that commonly deal with groundwater chemistry, arsenite is used generically to identify soluble AsIII anions. IUPAC have recommended that arsenite compounds are to be named as arsenate(III), for example ortho-arsenite is called trioxidoarsenate(III). Ortho-arsenite contrasts to the corresponding anions of the lighter members of group 15, phosphite which has the structure and nitrite, which is bent. A number of different arsenite anions are known: * ortho-arsenite, an ion of arsenous acid, with a pyramidal shape * meta-arsenite, a polymeric chain anion. * pyro-arsenite, * a polyarsenite, * a polyarsenite, *, a polymeric anion In all of these the geometry around the AsIII centers are approximately trigonal, the lone pair on the arsenic atom is stereochemically active. Well known examples of arsenites include sodium meta-arsenite which contai ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antimonite
In chemistry, antimonite refers to a salt of antimony(III), such as NaSb(OH)4 and NaSbO2 (meta-antimonite), which can be prepared by reacting alkali with antimony trioxide, Sb2O3.Egon Wiberg, Arnold Frederick Holleman (2001) ''Inorganic Chemistry'', Elsevier These are formally salts of antimonous acid, Sb(OH)3, whose existence in solution is dubious. Attempts to isolate it generally form Sb2O3·''x''H2O, antimony(III) oxide hydrate, which slowly transforms into Sb2O3. In geology, the mineral stibnite, Sb2S3, is sometimes called antimonite. Antimonites can be compared to antimonate In chemistry an antimonate is a compound which contains a metallic element, oxygen, and antimony in an oxidation state of +5. These compounds adopt polymeric structures with M-O-Sb linkages. They can be considered to be derivatives of the hypothetic ...s, which contain antimony in the +5 oxidation state. References Antimony(III) compounds Oxyanions {{inorganic-compound-stub th:สติบไ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arsenite-Antimonite Efflux
Arsenite-antimonite transporters are membrane transporters that pump arsenite or antimonite out of a cell. Antimonite is the salt of antimony (Sb(III)) and has been found to significantly impact the toxicity of arsenite. The similar structure of As(III) and Sb(III) makes it plausible that certain transporters function in the efflux of both substrates. Arsenic efflux transporters exist in almost every organism and serve to remove this toxic compound from the cell. Subfamilies As of early 2016, there are at least three known families of proteins known to participate in arsenite and antimonite efflux. * ArsB familyTC# 2.A.45 * ArsAB FamilyTC# 3.A.4 * Arsenical resistance-3 (ARC3) familyTC#2.A.59 The membrane transporter ArsB can function as a secondary carrier or as a primary active transporter, in which case ArsA, an ATPase, must be superimposed onto ArsB. Arsenite and antimonite can also be pumped out of the cell by members of the ARC3 family, a member of the BART superfami ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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