AR-231,453
AR-231,453 is an agonist for the suggested novel cannabinoid receptor GPR119 G protein-coupled receptor 119 also known as GPR119 is a G protein-coupled receptor that in humans is encoded by the ''GPR119'' gene. GPR119, along with GPR55 and GPR18, have been implicated as novel cannabinoid receptors. Pharmacology GPR119 .... See also * PSN-375,963 * PSN-632,408 References Drugs not assigned an ATC code Cannabinoids Benzosulfones Nitropyrimidines Piperidines Oxadiazoles Aromatic amines Fluoroarenes Anilines Isopropyl compounds {{Cannabinoid-stub ...
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GPR119
G protein-coupled receptor 119 also known as GPR119 is a G protein-coupled receptor that in humans is encoded by the ''GPR119'' gene. GPR119, along with GPR55 and GPR18, have been implicated as novel cannabinoid receptors. Pharmacology GPR119 is expressed predominantly in the pancreas and gastrointestinal tract in rodents and humans, as well as in the brain in rodents. Activation of the receptor has been shown to cause a reduction in food intake and body weight gain in rats. GPR119 has also been shown to regulate incretin and insulin hormone secretion. As a result, new drugs acting on the receptor have been suggested as novel treatments for obesity and diabetes. Ligands A number of endogenous and synthetic ligands for this receptor have been identified: * 2-Oleoylglycerol * Anandamide * AR-231,453 * MBX-2982 * Oleoylethanolamide (Endogenous Ligand) * PSN-375,963 * PSN-632,408 PSN-632,408 is a selective ligand for the suggested novel cannabinoid receptor GPR119. See ...
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