AP-1 Promoter Complex
AP1 or AP-1 may refer to: Biology * Activator protein 1, dimeric transcription factor * Adaptor protein 1, tetrameric clathrin-associated complex Transportation * Autopista AP-1, a Spanish motorway * Caproni A.P.1, a 1934 Italian attack aircraft monoplane * USS ''Henderson'' (AP-1) Other uses * Protocol I, or AP 1, a 1977 amendment to the Geneva Conventions See also * API (other) An API, or application programming interface, is any defined inter-program interface. API or api may also refer to: Companies and organizations * Academic Programs International, an American study-abroad provider * American Petroleum Instit ...

Activator Protein 1
Activator protein 1 (AP-1) is a transcription factor that regulates gene expression in response to a variety of stimuli, including cytokines, growth factors, stress, and bacterial and viral infections. AP-1 controls a number of cellular processes including differentiation, proliferation, and apoptosis. The structure of AP-1 is a heterodimer composed of proteins belonging to the c-Fos, c-Jun, ATF and JDP families. History AP-1 was first discovered as a TPA-activated transcription factor that bound to a cis-regulatory element of the human metallothionein IIa ( hMTIIa) promoter and SV40. The AP-1 binding site was identified as the 12-O-Tetradecanoylphorbol-13-acetate ( TPA) response element (TRE) with the consensus sequence 5’-TGA G/C TCA-3’. The AP-1 subunit Jun was identified as a novel oncoprotein of avian sarcoma virus, and Fos-associated p39 protein was identified as the transcript of the cellular Jun gene. Fos was first isolated as the cellular homologue ...
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Adaptor Protein 1
Clathrin adaptor proteins, also known as adaptins, are proteins that mediate the formation of vesicles for intracellular trafficking and secretion. Adaptins are clustered subunits of adaptor protein (AP) complexes. There are several types of adaptin, each related to a different AP complex. Adaptins show sequence similarity to some COPI subunits, thus they are thought to have a common evolutionary origin. The adaptin is a heterotetramer consisting of two large adaptins (beta and one other depending on the complex), a medium adaptin (mu), and a small adaptin (sigma): * complex 1 ** AP1B1 ** AP1G1 ** AP1G2 ** AP1M1 ** AP1M2 ** AP1S1 ** AP1S2 *AP1S3* complex 2 ** AP2A1 ** AP2A2 ** AP2B1 ** AP2M1 ** AP2S1 * complex 3 ** AP3B1 ** AP3B2 ** AP3D1 ** AP3M1 *AP3M2** AP3S1 ** AP3S2 * complex 4 ** AP4B1 ** AP4E1 ** AP4M1 ** AP4S1 * complex 5 ** AP5Z1 AP-5 complex subunit zeta (AP5Z1) is a protein that in humans is encoded by the ''AP5Z1'' gene. Function The protein encoded by this ...
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Autopista AP-1
The Autopista AP-1 (also known in Spanish as ''Autopista del Norte'') is a Spanish '' autopista''. It has two separate sections: the first from Burgos to Armiñón, and the second from Etxabarri Ibiña (a hamlet close to Vitoria-Gasteiz) to Eibar. In Eibar, at the ''Malzaga'' junction, AP-1 meets Autopista AP-8, which connects with Irun and the French border. The first section became toll-free in 2018. However, it has kept the AP prefix, usually reserved to tolled motorways. See also * Autovía A-1 * Carretera Nacional N-I The N-I was the former main road from Madrid to France in Spain. Most of the route has now been replaced by the Autovía A-1 and Autopista AP-1. The A-1 starts at Madrid then goes to Burgos. N-I then runs parallel to AP-1 (toll highway) to Mira ... References External linksAutopista AP-1 Concessionaire {{DEFAULTSORT:AP-1 Autopistas and autovías in Spain Transport in Castile and León Roads in the Basque Country (autonomous community) ...
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Caproni A
Caproni, also known as ''Società de Agostini e Caproni'' and ''Società Caproni e Comitti'', was an Italian aircraft manufacturer. Its main base of operations was at Taliedo, near Linate Airport, on the outskirts of Milan. Founded by Giovanni Battista "Gianni" Caproni during 1908, the company produced several successful heavy bombers during the First World War. Following the acquisition of several other aviation firms throughout the interwar period, Caproni transformed into a sizable aviation-orientated syndicate, the ''Società Italiana Caproni, Milano''. The majority of its aircraft were bombers and transport aircraft. It played a pioneering role in the development of the Caproni Campini N.1, an experimental aircraft powered by a thermo-jet. It provided large numbers of combat aircraft for the Axis during the Second World War. The firm did not prosper in the postwar era, the Società Italiana Caproni collapsing during 1950. Many of the company's former assets were subseque ...
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USS Henderson (AP-1)
The first USS ''Henderson'' (AP-1) was a transport in the United States Navy during World War I and World War II. In 1943, she was converted to a hospital ship and commissioned as USS ''Bountiful'' (AH-9). Named for Marine Colonel Archibald Henderson, she was launched by Philadelphia Navy Yard on 17 June 1916; sponsored by Miss Genevieve W. Taylor, great-granddaughter of General Henderson; and commissioned at Philadelphia, Pennsylvania on 24 May 1917. Service history World War I, 1917–1918 ''Henderson'' arrived New York on 12 June 1917 and sailed two days later with Rear Admiral Albert Gleaves' Cruiser and Transport Force, which carried units of the American Expeditionary Force to France. In her holds she had space for 1,500 men and 24 mules. Reaching Saint-Nazaire on 27 June she disembarked troops and returned to Philadelphia on 17 July 1917. Subsequently, ''Henderson'' made eight more voyages to France with troops and supplies for the allies in the bitter European fightin ...
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Protocol I
Protocol I (sometimes referred to as Additional Protocol I or AP 1) is a 1977 amendment protocol to the Geneva Conventions relating to the protection of victims of ''international conflicts'', extending to "armed conflicts in which peoples are fighting against colonial domination, alien occupation or racist regimes" are to be considered international conflicts. It reaffirms the international laws of the original Geneva Conventions of 1949, but adds clarifications and new provisions to accommodate developments in modern international warfare that have taken place since the Second World War. Ratification status As of February 2020, it had been ratified by 174 states, with the United States, Israel, Iran, Pakistan, India, and Turkey being notable exceptions. However, the United States, Iran, and Pakistan signed it on 12 December 1977, which signifies an intention to work towards ratifying it. The Iranian Revolution has occurred in the interim. Russia On 16 October 2019, Pr ...
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