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AM Cannabinoids
Alexandros Makriyannis is a professor in the Department of Medicinal Chemistry at Northeastern University, where his research group has synthesized many new compounds with cannabinoid activity. Some of those are: See also * List of CP cannabinoids * List of JWH cannabinoids * List of HU cannabinoids * List of miscellaneous designer cannabinoids Since the first synthetic cannabinoids were discovered in recreational drug products in 2008, new synthetic cannabinoids with no precedent in the scientific literature continue to be identified. These synthetic cannabinoids appear to be rationally ... References {{Cannabinoids ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alexandros Makriyannis
Alexandros Makriyannis (born September 9, 1939) is an American biochemist and professor of Chemistry and Chemical Biology in the Department of Medicinal Chemistry at Northeastern University in Boston, Massachusetts, where he directs the Center for Drug Discovery and holds the George Behrakis Chair of Pharmaceutical Biotechnology. His research has focused on the biochemical basis of the endocannabinoid system and on the development of synthetic cannabinoids. Scientific career Makriyannis studied chemistry at the University of Cairo. He then earned his Ph.D. in medicinal chemistry at the University of Kansas and went on to research synthetic organic chemistry at the University of California, Berkeley. He worked at Smith, Kline & French Laboratories and Tufts Medical School and then at the University of Connecticut, where he was later appointed Distinguished Professor of Medicinal Chemistry and Professor of Molecular and Cell Biology and Pharmacology. He moved to Northeastern Universi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
AM-374 (drug)
USS ''Pigeon'' (AM-374) was an acquired by the United States Navy for the dangerous task of removing mines from minefields laid in the water to prevent ships from passing. ''Pigeon'' was laid down 10 November 1944 by the Savannah Machine and Foundry Co., Savannah, Georgia; launched 28 March 1945; sponsored by Miss Jean Ross; and commissioned at Savannah on 30 October 1945. Decommissioned and reactivated After fitting out at the Charleston Navy Yard and operations out of the Naval Mine Warfare School, Yorktown, Virginia, ''Pigeon'' was decommissioned on 10 July 1946. Following Communist aggression in Korea, she was recommissioned at Orange, Texas, on 30 November 1950. North Atlantic operations ''Pigeon'' departed Orange, Texas, on 2 January 1951 to join Mine Squadron 8 at Charleston, South Carolina. Tactics and Atlantic Fleet exercises took her to Norfolk, Virginia, and to Cuba, Puerto Rico, and the Virgin Islands. On 25 August 1952 she departed Charleston, with Mine Divi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
JWH018
{{disambig ...
JWH may refer to: * John Wesley Hardin, an American gun-fighter from the 18th century * John W. Henry, futures trader and owner of the Boston Red Sox * John Winston Howard, former Prime Minister of Australia * JWH-133, a medication used to prevent Alzheimer's disease * John W. Huffman, creator of the JWH cannabinoids * Jared Waerea Hargreaves- New Zealand rugby league player for the Manly Sea Eagles The Manly Warringah Sea Eagles are an Australian professional rugby league club based in Sydney's Northern Beaches. The team colours are maroon and white, while their namesake and logo is the sea eagle. They compete in Australia's premier rugb ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
AM-678
JWH-018 (1-pentyl-3-(1-naphthoyl)indole, NA-PIMO or AM-678) is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with some selectivity for CB2. It produces effects in animals similar to those of tetrahydrocannabinol (THC), a cannabinoid naturally present in cannabis, leading to its use in synthetic cannabis products that in some countries are sold legally as "incense blends". As a full agonist at both the CB1 and CB2 cannabinoid receptors, this chemical compound is classified as an analgesic medication. The analgesic effects of cannabinoid ligands, mediated by CB1 receptors are well established in treatment of neuropathic pain, as well as cancer pain and arthritis. These compounds work by mimicking the body's naturally-produced endocannabinoid hormones such as 2-AG and anandamide (AEA), which are biologically active and can exacerbate or inhibit nerve signaling. As the cause is poorly understood in ch ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
AM-630 Structure
USS ''Skylark'' (AM-63) was an built for the United States Navy during World War II. She earned three battle stars during World War II. ''Skylark'' was mined and sunk off Okinawa in April 1945. She was struck from the Naval Vessel Register the same day. Career ''Skylark'' was laid down on 9 July 1941 by the General Engineering & Dry Dock Company of Alameda, California; launched on 12 March 1942; sponsored by Mrs. William L. Simpson; and commissioned on 25 November 1942. After almost a month of trials, calibrations, and training along the coast of California, ''Skylark'' got underway for Pearl Harbor, Hawaii, on the morning of 20 December. The convoy arrived in Pearl Harbor ten days later, and ''Skylark'' remained in the Islands for another eleven days. On 10 January 1943, she stood out of Pearl Harbor and set course for Espiritu Santo in the New Hebrides, escorting another convoy. For the next year, ''Skylark'' escorted convoys around the various island groups in the South ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
AM-630
AM-630 (6-Iodopravadoline) is a drug that acts as a potent and selective inverse agonist for the cannabinoid receptor CB2, with a ''K''i of 32.1 nM at CB2 and 165x selectivity over CB1, at which it acted as a weak partial agonist. It is used in the study of CB2 mediated responses and has been used to investigate the possible role of CB2 receptors in the brain. AM-630 is significant as one of the first indole derived cannabinoid ligands substituted on the 6-position of the indole ring, a position that has subsequently been found to be important in determining affinity and efficacy at both the CB1 and CB2 receptors, and has led to the development of many related derivatives. See also * AM-1221 * Pravadoline * WIN 54,461 WIN 54,461 (6-Bromopravadoline) is a drug that acts as a potent and selective inverse agonist for the cannabinoid receptor CB2. See also * AM-630 (6-Iodopravadoline) * WIN 48,098 (Pravadoline) * WIN 55,212-2 WIN 55,212-2 is a chemical des ... (6-Br ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Full Agonist
An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the agonist, while an inverse agonist causes an action opposite to that of the agonist. Etymology From the Greek αγωνιστής (agōnistēs), contestant; champion; rival < αγων (agōn), contest, combat; exertion, struggle < αγω (agō), I lead, lead towards, conduct; drive Types of agonists can be activated by either endogenous agonists (such as |
Adamantane
Adamantane is an organic compound with a formula C10H16 or, more descriptively, (CH)4(CH2)6. Adamantane molecules can be described as the fusion of three cyclohexane rings. The molecule is both rigid and virtually stress-free. Adamantane is the most stable isomer of C10H16. The spatial arrangement of carbon atoms in the adamantane molecule is the same as in the diamond crystal. This similarity led to the name ''adamantane'', which is derived from the Greek ''adamantinos'' (relating to steel or diamond). It is a white solid with a camphor-like odor. It is the simplest diamondoid. The discovery of adamantane in petroleum in 1933 launched a new field of chemistry dedicated to the synthesis and properties of polyhedral organic compounds. Adamantane derivatives have found practical application as drugs, polymeric materials, and thermally stable lubricants. History and synthesis In 1924, H. Decker suggested the existence of adamantane, which he called decaterpene. The first attempted ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
AM-411
AM-411 (part of the AM cannabinoid series) is an analgesic drug that is a cannabinoid agonist. It is a derivative of Δ8-THC substituted with an adamantyl group at the 3-position, demonstrating that the binding pocket for the alkyl chain at this position can accommodate significant bulk. AM-411 is a potent and fairly selective CB1 full agonist with a Ki of 6.80 nM, but is still also a moderately potent CB2 agonist with a Ki of 52.0 nM. It produces similar effects to other cannabinoid agonists such as analgesia, sedation, and anxiolysis. See also * AM-087 * AM-1248 * KM-233 KM-233 is a synthetic cannabinoid drug which is a structural analog of Δ8-tetrahydrocannabinol (THC), the less active but more stable isomer of the active component of ''Cannabis''. KM-233 differs from Δ8-THC by the pentyl side chain being r ... References Adamantanes Benzochromenes Phenols AM cannabinoids {{cannabinoid-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fatty Acid Amide Hydrolase
Fatty acid amide hydrolase or FAAH (, oleamide hydrolase, anandamide amidohydrolase) is a member of the serine hydrolase family of enzymes. It was first shown to break down anandamide in 1993. In humans, it is encoded by the gene ''FAAH''.; Function FAAH is an integral membrane hydrolase with a single ''N''-terminal transmembrane domain. ''In vitro'', FAAH has esterase and amidase activity. ''In vivo'', FAAH is the principal catabolic enzyme for a class of bioactive lipids called the fatty acid amides (FAAs). Members of the FAAs include: * Anandamide (''N''-arachidonoylethanolamine), an endocannabinoid * 2-arachidonoylglycerol (2-AG), an endocannabinoid. * Other ''N''-acylethanolamines, such as ''N''-oleoylethanolamine and ''N''-palmitoylethanolamine * The sleep-inducing lipid oleamide * The ''N''-acyltaurines, which are agonists of the transient receptor potential (TRP) family of calcium channels. ''FAAH'' knockout mice display highly elevated (>15-fold) levels of ''N'' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acetaminophen
Paracetamol, also known as acetaminophen, is a medication used to treat fever and mild to moderate pain. Common brand names include Tylenol and Panadol. At a standard dose, paracetamol only slightly decreases body temperature; it is inferior to ibuprofen in that respect, and the benefits of its use for fever are unclear. Paracetamol may relieve pain in acute mild migraine but only slightly in episodic tension headache. However, the aspirin/paracetamol/caffeine combination helps with both conditions where the pain is mild and is recommended as a first-line treatment for them. Paracetamol is effective for post-surgical pain, but it is inferior to ibuprofen. The paracetamol/ibuprofen combination provides further increase in potency and is superior to either drug alone. The pain relief paracetamol provides in osteoarthritis is small and clinically insignificant. The evidence in its favor for the use in low back pain, cancer pain, and neuropathic pain is insufficient. In the short ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
