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A. Hari Reddi
A. Hari Reddi (born October 20, 1942) is a Distinguished Professor and holder of the Lawrence J. Ellison Endowed Chair in Musculoskeletal Molecular Biology at the University of California, Davis. He was previously the Virginia M. and William A. Percy Chair and Professor in Orthopaedic Surgery, Professor of Biological Chemistry, and Professor of Oncology at the Johns Hopkins University School of Medicine. Professor Reddi's research played an indispensable role in the identification, isolation and purification of bone morphogenetic proteins (BMPs) that are involved in bone formation and repair. The molecular mechanism of bone induction studied by Professor Reddi led to the conceptual advance in tissue engineering that morphogens in the form of metabologens bound to an insoluble extracellular matrix scaffolding act in collaboration to stimulate stem cells to form cartilage and bone. The Reddi laboratory has also made important discoveries unraveling the role of the extracellular ma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Delhi
Delhi University (DU), formally the University of Delhi, is a collegiate central university located in New Delhi, India. It was founded in 1922 by an Act of the Central Legislative Assembly and is recognized as an Institute of Eminence (IoE) by the University Grants Commission (UGC). As a collegiate university, its main functions are divided between the academic departments of the university and constituent colleges. Consisting of three colleges, two faculties, and 750 students at its founding, the University of Delhi has since become India's largest institution of higher learning and among the largest in the world. The university has 16 faculties and 86 departments distributed across its North and South campuses, and remaining colleges across the region. It has 91 constituent colleges. The Vice President of India serves as the university chancellor. History The University of Delhi was established in 1922 as a unitary, teaching and residential university by an Act of the the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Johns Hopkins University School Of Medicine
The Johns Hopkins University School of Medicine (JHUSOM) is the medical school of Johns Hopkins University, a private research university in Baltimore, Maryland. Founded in 1893, the School of Medicine shares a campus with the Johns Hopkins Hospital and Johns Hopkins Children's Center, established in 1889. It has consistently ranked among the top medical schools in the United States in terms of the number/amount of research grants/funding awarded by the National Institutes of Health, among other measures. History The founding physicians (the "Four Doctors") of the Johns Hopkins School of Medicine included pathologist William Henry Welch (1850–1934), the first dean of the school and a mentor to generations of research scientists; a Canadian, internist Sir William Osler (1849–1919), regarded as the ''Father of Modern Medicine'', having been perhaps the most influential physician of the late 19th and early 20th centuries as author of '' The Principles and Practice of Medicine'' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Association Of Bone And Joint Surgeons
''Clinical Orthopaedics and Related Research'' is a peer-reviewed medical journal. It was established in 1953 as ''Clinical Orthopaedics'' by the Association of Bone and Joint Surgeons as an alternative to the ''Journal of Bone and Joint Surgery'', which was the only American orthopaedic journal at the time. The journal obtained its current title in 1963 and its mission is to disseminate knowledge about all aspects of musculoskeletal The human musculoskeletal system (also known as the human locomotor system, and previously the activity system) is an organ system that gives humans the ability to move using their muscular and skeletal systems. The musculoskeletal system prov ... research, diagnoses, and treatment. In conjunction with ''Clinical Orthopaedics and Related Research'', the Association of Bone and Joint Surgeons presents three awards annually including the Nicolas Andry Award. References External links * {{Official website, http://www.clinorthop.org/index.html ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Academy Of Orthopaedic Surgeons
The American Academy of Orthopaedic Surgeons (AAOS) is an orthopedic organization. Founded at Northwestern University in 1933, as of 2015 AAOS had grown to include about 39,000 members.AAOMembersPage accessed June 27, 2015 The group provides education and practice management services for orthopedic surgeons and allied health professionals. It also lobbies and works on public education. It describes itself as "the world's largest medical association of musculoskeletal The human musculoskeletal system (also known as the human locomotor system, and previously the activity system) is an organ system that gives humans the ability to move using their muscular and skeletal systems. The musculoskeletal system prov ... specialists." It is a provider of musculoskeletal education to orthopaedic surgeons and others. Its continuing medical education activities include an annual meeting, multiple CME courses held around the country and at the Orthopaedic Learning Center, and various med ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Peyton Rous
Francis Peyton Rous () (October 5, 1879 – February 16, 1970) was an American pathologist at the Rockefeller University known for his works in oncoviruses, blood transfusion and physiology of digestion. A medical graduate from the Johns Hopkins University, he was discouraged to become a practicing physician due to severe tuberculosis. After three years of working as an instructor of pathology at the University of Michigan, he became dedicated researcher at the Rockefeller Institute for Medical Research for the rest of his career. His discovery in 1911 that a chicken tumor was caused by a virus (later named Rous sarcoma virus) led to more discoveries and understanding of the role of viruses in the development of certain types of cancer. He was awarded a Nobel Prize in Physiology or Medicine for his work in 1966, 55 years after his initial discovery and he remains the oldest recipient of the Nobel Prize in Medicine or Physiology. He and Joseph R. Turner studied methods to make ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Charles Brenton Huggins
Charles Brenton Huggins (September 22, 1901 – January 12, 1997) was a Canadian-American physician, physiologist and cancer researcher at the University of Chicago specializing in prostate cancer. He was awarded the 1966 Nobel Prize for Physiology or Medicine for discovering in 1941 that hormones could be used to control the spread of some cancers. This was the first discovery that showed that cancer could be controlled by chemicals. Biography Huggins was born in Halifax, Nova Scotia, Canada. He graduated from Acadia University with a BA degree in 1920. He went on to study medicine at Harvard Medical School and received his MD degree in 1924. He served his internship and residency in general surgery with Frederick A. Coller at the University of Michigan. Huggins established a method to measure the effect hormone changes have on prostatic function. He found out that castration or estrogen administration led to glandular atrophy, which could be reversed by re-administration ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Malur R
Malur (Kannada - ಮಾಲೂರು) is a town and taluk headquarters in Kolar district of the Indian state of Karnataka. It is 30 km from Kolar, the district headquarters, and about 25 km from Bangalore. It is accessible from Bangalore by road and railways. The Chennai Central-Bangalore City line passes through Malur, with trains to various parts of India, including Tirupati, Chennai, Kochi, Trivandrum, Patna and Calcutta. Geography Malur is located at . It has an average elevation of . It has a Tropical wet and dry climate, similar to Bangalore. It has summer temperatures rarely crossing 37°C, and winter temperatures rarely falling below 15°C. Demographics India Census,{{cite web, url=http://www.censusindia.net/results/town.php?stad=A&state5=999, archive-url=https://web.archive.org/web/20040616075334/http://www.censusindia.net/results/town.php?stad=A&state5=999, archive-date=2004-06-16, title= Census of India 2001: Data from the 2001 Census, including cities, villages an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stem Cells
In multicellular organisms, stem cells are undifferentiated or partially differentiated cells that can differentiate into various types of cells and proliferate indefinitely to produce more of the same stem cell. They are the earliest type of cell in a cell lineage. They are found in both embryonic and adult organisms, but they have slightly different properties in each. They are usually distinguished from progenitor cells, which cannot divide indefinitely, and precursor or blast cells, which are usually committed to differentiating into one cell type. In mammals, roughly 50–150 cells make up the inner cell mass during the blastocyst stage of embryonic development, around days 5–14. These have stem-cell capability. ''In vivo'', they eventually differentiate into all of the body's cell types (making them pluripotent). This process starts with the differentiation into the three germ layers – the ectoderm, mesoderm and endoderm – at the gastrulation stage. However, when ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Metabologen
A metabologen is defined as a morphogen (molecule) that can initiate, promote and maintain metabolism and homeostasis. Based on this definition, bone morphogenetic proteins (BMPs) are metabologens, since they are involved in iron homeostasis, brown fat adipogenesis Adipogenesis is the formation of adipocytes (fat cells) from stem cells. It involves 2 phases, determination, and terminal differentiation. Determination is mesenchymal stem cells committing to the adipocyte precursor cells, also known as preadipocy ... and energy metabolism. Professor A. Hari Reddi anAnand Reddiin ''Cytokine Growth Factor Rev'' were the first to propose the term metabologen (as reviewed in a special issue of ''Cytokine Growth Factor Review'' guest edited by Dr. A. Hari Reddi entitled Bone Morphogenetic Proteins, Stem Cells and Regenerative Medicine.). References Morphogens {{developmental-biology-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tissue Engineering
Tissue engineering is a biomedical engineering discipline that uses a combination of Cell (biology), cells, engineering, Materials science, materials methods, and suitable biochemistry, biochemical and physicochemical factors to restore, maintain, improve, or replace different types of biology, biological tissues. Tissue engineering often involves the use of cells placed on tissue scaffolds in the formation of new viable tissue for a medical purpose but is not limited to applications involving cells and tissue scaffolds. While it was once categorized as a sub-field of biomaterials, having grown in scope and importance it can be considered as a field of its own. While most definitions of tissue engineering cover a broad range of applications, in practice the term is closely associated with applications that repair or replace portions of or whole tissues (i.e. bone, Autologous chondrocyte implantation, cartilage, blood vessels, Urinary bladder, bladder, skin, muscle etc.). Often, t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bone Morphogenetic Proteins
Bone morphogenetic proteins (BMPs) are a group of growth factors also known as cytokines and as metabologens. Originally discovered by their ability to induce the formation of bone and cartilage, BMPs are now considered to constitute a group of pivotal morphogenetic signals, orchestrating tissue architecture throughout the body. The important functioning of BMP signals in physiology is emphasized by the multitude of roles for dysregulated BMP signalling in pathological processes. Cancerous disease often involves misregulation of the BMP signalling system. Absence of BMP signalling is, for instance, an important factor in the progression of colon cancer, and conversely, overactivation of BMP signalling following reflux-induced esophagitis provokes Barrett's esophagus and is thus instrumental in the development of esophageal adenocarcinoma. Recombinant human BMPs (rhBMPs) are used in orthopedic applications such as spinal fusions, nonunions, and oral surgery. rhBMP-2 and rhBMP-7 are F ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of California, Davis
The University of California, Davis (UC Davis, UCD, or Davis) is a public land-grant research university near Davis, California. Named a Public Ivy, it is the northernmost of the ten campuses of the University of California system. The institution was first founded as an agricultural branch of the system in 1905 and became the seventh campus of the University of California in 1959. The university is classified among "R1: Doctoral Universities – Very high research activity". The UC Davis faculty includes 23 members of the National Academy of Sciences, 30 members of the American Academy of Arts and Sciences, 17 members of the American Law Institute, 14 members of the Institute of Medicine, and 14 members of the National Academy of Engineering. Among other honors that university faculty, alumni, and researchers have won are two Nobel Prizes, one Fields Medal, a Presidential Medal of Freedom, three Pulitzer Prizes, three MacArthur Fellowships, and a National Medal of Scien ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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