A. Hari Reddi (born October 20, 1942) is a Distinguished Professor and holder of the Lawrence J. Ellison Endowed Chair in Musculoskeletal Molecular Biology at the

University of California, Davis The University of California, Davis (UC Davis, UCD, or Davis) is a public land-grant research university near Davis, California. Named a Public Ivy, it is the northernmost of the ten campuses of the University of California system. The institut ...

. He was previously the Virginia M. and William A. Percy Chair and Professor in Orthopaedic Surgery, Professor of Biological Chemistry, and Professor of Oncology at the

Johns Hopkins University School of Medicine The Johns Hopkins University School of Medicine (JHUSOM) is the medical school of Johns Hopkins University, a private research university in Baltimore, Maryland. Founded in 1893, the School of Medicine shares a campus with the Johns Hopkins Hospi ...

. Professor Reddi's research played an indispensable role in the identification, isolation and purification of

bone morphogenetic proteins Bone morphogenetic proteins (BMPs) are a group of growth factors also known as cytokines and as metabologens. Originally discovered by their ability to induce the formation of bone and cartilage, BMPs are now considered to constitute a group of piv ...

(BMPs) that are involved in bone formation and repair. The molecular mechanism of bone induction studied by Professor Reddi led to the conceptual advance in

tissue engineering Tissue engineering is a biomedical engineering discipline that uses a combination of Cell (biology), cells, engineering, Materials science, materials methods, and suitable biochemistry, biochemical and physicochemical factors to restore, maintai ...

that morphogens in the form of

metabologen A metabologen is defined as a morphogen (molecule) that can initiate, promote and maintain metabolism and homeostasis. Based on this definition, bone morphogenetic proteins (BMPs) are metabologens, since they are involved in human iron metabolism, ...

s bound to an insoluble extracellular matrix scaffolding act in collaboration to stimulate

stem cells In multicellular organisms, stem cells are undifferentiated or partially differentiated cells that can differentiate into various types of cells and proliferate indefinitely to produce more of the same stem cell. They are the earliest type o ...

to form cartilage and bone. The Reddi laboratory has also made important discoveries unraveling the role of the extracellular matrix in bone and cartilage tissue regeneration and repair.

Significant research accomplishments

Professor Reddi discovered that bone induction is a sequential multistep cascade involving chemotaxis, mitosis, and differentiation. Early studies in his laboratory at the

University of Chicago The University of Chicago (UChicago, Chicago, U of C, or UChi) is a private research university in Chicago, Illinois. Its main campus is located in Chicago's Hyde Park neighborhood. The University of Chicago is consistently ranked among the b ...

and

National Institutes of Health The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late ...

unraveled the sequence of events involved in bone matrix-induce bone morphogenesis. Using a battery of ''in vitro'' and ''in vivo'' bioassays for bone formation, a systematic study was undertaken in his laboratory to isolate and purify putative bone morphogenetic proteins. Reddi and colleagues were the first to identify BMPs as pleiotropic regulators, acting in a concentration dependent manner. They demonstrated first that BMPs bind the extracellular matrix, are present at the apical ectodermal ridge in the developing limb bud, are chemotactic for human monocytes, and have neurotropic potential. His laboratory pioneered the use of BMPs in regenerative orthopedics and dentistry.

Education and Mentors

Hari Reddi received his PhD from the

University of Delhi Delhi University (DU), formally the University of Delhi, is a collegiate central university located in New Delhi, India. It was founded in 1922 by an Act of the Central Legislative Assembly and is recognized as an Institute of Eminence (IoE) ...

in reproductive endocrinology under the mentorship of M.R.N. Prasad. Reddi did postdoctoral work wit
Howard Guy Williams-Ashman
at the Johns Hopkins University School of Medicine. Reddi was also a student of

Charles Brenton Huggins Charles Brenton Huggins (September 22, 1901 – January 12, 1997) was a Canadian-American physician, physiologist and cancer researcher at the University of Chicago specializing in prostate cancer. He was awarded the 1966 Nobel Prize for Physio ...

, the winner of the 1966 Nobel Prize with

Peyton Rous Francis Peyton Rous () (October 5, 1879 – February 16, 1970) was an American pathologist at the Rockefeller University known for his works in oncoviruses, blood transfusion and physiology of digestion. A medical graduate from the Johns Hopki ...

for the endocrine regulation of cancer.

International Conference of Bone Morphogenetic Proteins

Reddi is the founder of the International Conference on Bone Morphogenetic Proteins (BMPs). He organized the first conference at the Johns Hopkins University School of Medicine in 1994. The conference is held every two years rotating between the United States and an international venue.

Awards

*Kappa Delta Award for the "Purification, Cloning and Expression of Osteogenin, A Protein Initiator of Bone Differentiation." in 1991. *Marshall Urist Award for Excellence in Tissue Regeneration Research from the Orthopedic Research Society and the

American Academy of Orthopaedic Surgeons The American Academy of Orthopaedic Surgeons (AAOS) is an orthopedic organization. Founded at Northwestern University in 1933, as of 2015 AAOS had grown to include about 39,000 members.AAOMembersPage accessed June 27, 2015 The group provides edu ...

. in 1997. Professor Reddi was the first recipient of the Urist award. *Nicolas Andry Prize award from the

Association of Bone and Joint Surgeons ''Clinical Orthopaedics and Related Research'' is a peer-reviewed medical journal. It was established in 1953 as ''Clinical Orthopaedics'' by the Association of Bone and Joint Surgeons as an alternative to the ''Journal of Bone and Joint Surgery ...

in 1999. *Japanese Association for the Promotion of State-of-the-Art in Medicine prize in 2004. *BBVA Foundation Biomedicine Chair in 2007, enabling the attachment of leading international professors to universities in Spain. Professor Reddi was at the University of Malaga working on articular cartilage regeneration.

Books

Ramachandran, G.N., Reddi, A.H. (Eds.), Biochemistry of Collagen. Plenum Press, New York, NY, 1976. Piez, K.A., Reddi, A.H. (Eds.), Extracellular Matrix Biochemistry. Elsevier, New York, 1984. Reddi A.H. (Ed.), Extracellular Matrix: Structure and Function. A.R. Liss, New York, 1985. Habal, M.B. and Reddi, A.H. (Eds.), Bone Grafts and Bone Substitutes. W.B Saunders and Co., Philadelphia, PA, 1992. Athanasiou, K.A., Darling, E.M., Hu, J.C., DuRaine, G.D., Reddi, A.H., Articular Cartilage, 2nd Edition. (Hardback), CRC Press, 2017.

References

{{DEFAULTSORT:Reddi, A. Hari Biochemistry educators Bone morphogenetic protein Tissue engineering