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7-Keto-DHEA
7-Ketodehydroepiandrosterone (7-keto-DHEA,7-oxo-DHEA), also known as 7-oxoprasterone, is a prohormone produced by metabolism of the prohormone dehydroepiandrosterone (DHEA). 7-oxo-DHEA is even more effective than DHEA for inducing heat production (thermogenesis). Because dieting is usually accompanied by reduced resting metabolic rate, obese persons may benefit from using 7-oxo-DHEA when dieting due to increased metabolic rate. 7-Keto-DHEA is not directly converted to testosterone or estrogen, and has thus been investigated as a potentially more useful relative of DHEA. Researchers have raised concern that supplements may trigger positive tests for performance-enhancing drugs. The World Anti-Doping Agency lists 7-keto-DHEA as a prohibited anabolic agent. The FDA has proposed that it be banned from use in compounded drugs. Chemistry 7-Keto-DHEA has a number of chemical names, including: * 7-Ketodehydroepiandrosterone (7-keto-DHEA) * 7-Oxodehydroepiandrosterone (7-oxo-DHEA) * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Prohormone
A prohormone is a committed precursor of a hormone consisting of peptide hormones synthesized together that has a minimal hormonal effect by itself because of its expression-suppressing structure, often created by protein folding and binding additional peptide chains to certain ends, that makes hormone receptor binding sites located on its peptide hormone chain segments inaccessible. Prohormones can travel the blood stream as a hormone in an inactivated form, ready to be activated later in the cell by post-translational modification. The body naturally produces prohormones as a way to regulate hormone expression, making them an optimal storage and transportation unit for inactive hormones. Once prohormones are needed to be expressed, prohormone convertase, a protein, cleaves the prohormones and separates them into one or more active hormones. Often in nature, this cleaving process happens immediately, and a prohormone is quickly converted to a set of one or more peptide hormones. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Science-Based Medicine
''Science-Based Medicine'' is a website and blog with articles covering issues in science and medicine, especially medical scams and practices. Founded in 2008, it is owned and operated by the New England Skeptical Society and run by Steven Novella, David Gorski, and Harriet Hall. History Started as a skeptically-based medical blog with five writers, ''Science-Based Medicine'' (SBM) launched on January 1, 2008. Steven Novella, a clinical neurologist at Yale University, Harriet Hall, and David Gorski were founding editors, along with Mark Crislip and Kimball Attwood. ''Science-Based Medicine'' is owned an operated by the New England Skeptical Society (NESS), where Novella, the long-standing executive editor of SBM, has also served as the president since inception. Gorski, a surgical oncologist at Wayne State University, serves as the managing editor for SBM. The ''Science-Based Medicine'' blog is affiliated with the Society for Science-Based Medicine (SfSBM), an opinionat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Androstanes
An androgen (from Greek ''andr-'', the stem of the word meaning "man") is any natural or synthetic steroid hormone that regulates the development and maintenance of male characteristics in vertebrates by binding to androgen receptors. This includes the embryological development of the primary male sex organs, and the development of male secondary sex characteristics at puberty. Androgens are synthesized in the testes, the ovaries, and the adrenal glands. Androgens increase in both males and females during puberty. The major androgen in males is testosterone. Dihydrotestosterone (DHT) and androstenedione are of equal importance in male development. DHT ''in utero'' causes differentiation of the penis, scrotum and prostate. In adulthood, DHT contributes to balding, prostate growth, and sebaceous gland activity. Although androgens are commonly thought of only as male sex hormones, females also have them, but at lower levels: they function in libido and sexual arousal. Also, and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
7β-Hydroxyepiandrosterone
7β-Hydroxyepiandrosterone (7β-OH-EPIA), also known as 5α-androstan-3β,7β-diol-17-one, is an endogenous androgen, estrogen, and neurosteroid that is produced from dehydroepiandrosterone and epiandrosterone. It has neuroprotective effects and, along with 7α-hydroxyepiandrosterone, may mediate the neuroprotective effects of DHEA. 7β-OH-EPIA may act as a highly potent antagonist An antagonist is a character in a story who is presented as the chief foe of the protagonist. Etymology The English word antagonist comes from the Greek ἀνταγωνιστής – ''antagonistēs'', "opponent, competitor, villain, enemy, ri ... of the G protein-coupled estrogen receptor (GPER) (affinity of <1 nM). References 5α-Reduced steroid metabolites[...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
7α-Hydroxyepiandrosterone
7α-Hydroxyepiandrosterone (7α-OH-EPIA), also known as 3β,7α-dihydroxy-5α-androstan-17-one, is an endogenous, naturally occurring metabolite of epiandrosterone and dehydroepiandrosterone (DHEA) that is formed by the enzyme CYP7B1 in tissues such as the liver and brain. See also * 7β-Hydroxyepiandrosterone 7β-Hydroxyepiandrosterone (7β-OH-EPIA), also known as 5α-androstan-3β,7β-diol-17-one, is an endogenous androgen, estrogen, and neurosteroid that is produced from dehydroepiandrosterone and epiandrosterone. It has neuroprotective effects and, ... * 7α-Hydroxy-DHEA * 7β-Hydroxy-DHEA * 7-Oxo-DHEA References Androstanes Diols Ketones {{steroid-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
7β-Hydroxy-DHEA
7β-Hydroxydehydroepiandrosterone (7β-hydroxy-DHEA; 7β-OH-DHEA), also known as 3β,7β-dihydroxyandrost-5-ene-17-one, is an endogenous, naturally occurring steroid and a metabolite of dehydroepiandrosterone (DHEA). The major metabolic pathway of DHEA outside the liver is via 7-hydroxylation into 7α-OH-DHEA and 7β-OH-DHEA. 7β-OH-DHEA has weak antiestrogenic activity, selectively antagonizing the estrogen receptor ERβ. 7β-OH-DHEA is on the World Anti-Doping Agency list of prohibited substances in sporting. See also * 7-Keto-DHEA * 7α-Hydroxyepiandrosterone * 7β-Hydroxyepiandrosterone 7β-Hydroxyepiandrosterone (7β-OH-EPIA), also known as 5α-androstan-3β,7β-diol-17-one, is an endogenous androgen, estrogen, and neurosteroid that is produced from dehydroepiandrosterone and epiandrosterone. It has neuroprotective effects and, ... References Diols Androstanes Antiestrogens Ketones World Anti-Doping Agency prohibited substances {{steroid-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
7α-Hydroxy-DHEA
7α-Hydroxydehydroepiandrosterone (7α-hydroxy-DHEA; 7α-OH-DHEA), also known as 3β,7α-dihydroxyandrost-5-ene-17-one, is an endogenous, naturally occurring steroid and a major metabolite of dehydroepiandrosterone (DHEA) that is formed by CYP7B1 (steroid 7α-hydroxylase) in tissues such as the prostate gland and by CYP3A4 in the liver. The major metabolic pathway of DHEA outside the liver is via 7-hydroxylation into 7α-OH-DHEA and 7β-OH-DHEA. 7α-OH-DHEA has weak estrogenic activity, selectively activating the estrogen receptor ERβ. In addition, 7α-OH-DHEA may be responsible for the known antiglucocorticoid effects of DHEA. Serum levels of 7α-OH-DHEA have been found to be significantly elevated in patients with Alzheimer's disease. It is unclear what significance this may have, if any. 7α-OH-DHEA is on the World Anti-Doping Agency list of prohibited substances in sporting. See also * 7-Keto-DHEA * 7α-Hydroxyepiandrosterone * 7β-Hydroxyepiandrosterone 7β-Hydroxyep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
List Of Investigational Anxiolytics
This is a list of investigational anxiolytics, or anxiolytics that are currently under development for clinical use but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses. Generalized anxiety disorder * Agomelatine (AGO-178; Valdoxan) – melatonin MT1 and MT2 receptor agonist, 5-HT2C receptor antagonist* Riluzole sublingual (BHV-0223) – undefined mechanism of action * TGFK08AA – 5-HT1A [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pseudoscience
Pseudoscience consists of statements, beliefs, or practices that claim to be both scientific and factual but are incompatible with the scientific method. Pseudoscience is often characterized by contradictory, exaggerated or unfalsifiable claims; reliance on confirmation bias rather than rigorous attempts at refutation; lack of openness to evaluation by other experts; absence of systematic practices when developing hypotheses; and continued adherence long after the pseudoscientific hypotheses have been experimentally discredited. The demarcation between science and pseudoscience has scientific, philosophical, and political implications. Philosophers debate the nature of science and the general criteria for drawing the line between scientific theories and pseudoscientific beliefs, but there is general agreement on examples such as ancient astronauts, climate change denial, dowsing, evolution denial, Holocaust denialism, astrology, alchemy, alternative medicine, occu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adrenal Fatigue
Adrenal fatigue or hypoadrenia is a pseudo-scientific term used by alternative medicine providers to suggest that the adrenal glands are exhausted and unable to produce adequate quantities of hormones, primarily cortisol, due to chronic stress or infections. Quote: "There is no scientific basis for the existence of this disorder and no conclusive method for diagnosis." There is no scientific basis for the existence of adrenal fatigue, and the term should not be confused with a number of actual forms of adrenal dysfunction such as adrenal insufficiency or Addison's disease. The term "adrenal fatigue" was invented in 1998 by chiropractor James Wilson and applied to a collection of mostly non-specific symptoms. There is no scientific evidence supporting the concept of adrenal fatigue, and it is not recognized as a diagnosis by the scientific or medical communities. Neither the condition nor the symptoms have any stable or recognized definition. A systematic review found no evidence ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alternative Medicine
Alternative medicine is any practice that aims to achieve the healing effects of medicine despite lacking biological plausibility, testability, repeatability, or evidence from clinical trials. Complementary medicine (CM), complementary and alternative medicine (CAM), integrated medicine or integrative medicine (IM), and holistic medicine attempt to combine alternative practices with those of mainstream medicine. Alternative therapies share in common that they reside outside of medical science and instead rely on pseudoscience. Traditional practices become "alternative" when used outside their original settings and without proper scientific explanation and evidence. Frequently used derogatory terms for relevant practices are ''new age'' or ''pseudo-'' medicine, with little distinction from quackery. Some alternative practices are based on theories that contradict the established science of how the human body works; others resort to the supernatural or superstitious to explain ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Compounded Drug
In the field of pharmacy, compounding (performed in compounding pharmacies) is preparation of a custom formulation of a medication to fit a unique need of a patient that cannot be met with commercially available products. This may be done for medical reasons, such as administration in a different format (ex: tablet to liquid), to avoid a non-active ingredient the patient is allergic to, or to provide an exact dose that isn't commercially available. Medically necessary compounding is referred to as "traditional" compounding. It may also be done for medically optional reasons, such as preference of flavor or texture, or dietary restrictions. Hospital pharmacies typically engage in compounding medications for intravenous administration, whereas outpatient or community pharmacies typically engage in compounding medications for oral or topical administration. Due to the rising cost of compounding and drug shortages, some hospitals outsource their compounding needs to large-scale com ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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