This is a list of investigational

anxiolytic An anxiolytic (; also antipanic or antianxiety agent) is a medication or other intervention that reduces anxiety. This effect is in contrast to anxiogenic agents which increase anxiety. Anxiolytic medications are used for the treatment of anxi ...

s, or anxiolytics that are currently under development for clinical use but are not yet approved. Chemical/

generic Generic or generics may refer to: In business * Generic term, a common name used for a range or class of similar things not protected by trademark * Generic brand, a brand for a product that does not have an associated brand or trademark, other ...

names are listed first, with developmental code names, synonyms, and brand names in parentheses.

Generalized anxiety disorder

Agomelatine Agomelatine, sold under the brand names Valdoxan and Thymanax, among others, is an atypical antidepressant most commonly used to treat major depressive disorder and generalized anxiety disorder. One review found that it is as effective as other a ...

(AGO-178; Valdoxan) –

melatonin Melatonin is a natural product found in plants and animals. It is primarily known in animals as a hormone released by the pineal gland in the brain at night, and has long been associated with control of the sleep–wake cycle. In vertebrates ...

MT₁ and MT₂ receptor

agonist An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ago ...

, 5-HT_2C receptor antagonist

*

Riluzole Riluzole is a medication used to treat amyotrophic lateral sclerosis and other motor neuron diseases. Riluzole delays the onset of ventilator-dependence or tracheostomy in some people and may increase survival by two to three months. Riluzole is ...

sublingual (BHV-0223) – undefined mechanism of action

* TGFK08AA – 5-HT_1A receptor modulator

* TGW00AA (FKW00GA) – 5-HT_1A receptor agonist, 5-HT_2A receptor antagonis

*

Vilazodone Vilazodone, sold under the brand name Viibryd among others, is a medication used to treat major depressive disorder. It is taken by mouth. Common side effects include nausea, diarrhea, and trouble sleeping. Serious side effects may include in ...

(EMD-68843, SB-659746A; Viibryd) – 5-HT_1A receptor

partial agonist In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist. They may also be considered ligands which display both agonistic and antagonistic e ...

and serotonin reuptake inhibitor

Panic disorder

* Darigabat (PF-06372865) – GABA_A receptor positive allosteric modulatorbr>
* JNJ-61393215 –

orexin Orexin (), also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite. The most common form of narcolepsy, type 1, in which the individual experiences brief losses of muscle tone ("drop attacks" or cataplexy), ...

OX₁ receptor antagonis

* NBTX-001 (Xenon) –

NMDA receptor The ''N''-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel found in neurons. The NMDA receptor is one of three types of ionotropic glutamate receptors, the other two being AMPA rece ...

antagonis

Post-traumatic stress disorder

7-Oxoprasterone 7-Ketodehydroepiandrosterone (7-keto-DHEA,7-oxo-DHEA), also known as 7-oxoprasterone, is a prohormone produced by metabolism of the prohormone dehydroepiandrosterone (DHEA). 7-oxo-DHEA is even more effective than DHEA for inducing heat producti ...

(7-keto-DHEA; HBL-9001) – "

immunomodulator Immunotherapy or biological therapy is the treatment of disease by activating or suppressing the immune system. Immunotherapies designed to elicit or amplify an immune response are classified as ''activation immunotherapies,'' while immunotherap ...

" / undefined mechanism of actio

*

Acamprosate Acamprosate, sold under the brand name Campral, is a medication used along with counselling to treat alcohol use disorder. For label updates seFDA index page for NDA 021431/ref> Acamprosate is thought to stabilize chemical signaling in the brai ...

(SNC-102) – undefined mechanism of actio

*

BNC-210 BNC210 (also known as IW-2143 during its time licensed to Ironwood Pharmaceuticals) is an anxiolytic drug that acts via negative allosteric modulation of the α7-nicotinic acetylcholine receptor, by Bionomics Limited. It is currently being inv ...

(IW-2143) – " modulator" / undefined mechanism of actionDoggrell, S. A. (2007). Novel drugs and products in neuroscience. ''Drugs of the Future'', 32(11), 1007-1017. https://journals.prous.com/journals/servlet/xmlxsl/pk_journals.xml_summary_pr?p_JournalId=2&p_RefId=3853&p_IsPs=Y
*

Brexpiprazole Brexpiprazole, sold under the brand name Rexulti among others, is an atypical antipsychotic. It is a dopamine D2 receptor partial agonist and has been described as a "serotonin–dopamine activity modulator" (SDAM). The drug was approved by th ...

(Lu AF41156, OPC-34712; Rexulti) –

atypical antipsychotic The atypical antipsychotics (AAP), also known as second generation antipsychotics (SGAs) and serotonin–dopamine antagonists (SDAs), are a group of antipsychotic drugs (antipsychotic drugs in general are also known as major tranquilizers and ne ...

/ 5-HT_1A, D₂ and D₃ receptor partial agonist and 5-HT_2A, 5-HT_2B, 5-HT₇, α₁-adrenergic, α₂-adrenergic, and H₁ receptor antagonis

*

Iloperidone Iloperidone, commonly known as Fanapt and previously known as Zomaril, is an atypical antipsychotic for the treatment of schizophrenia. Medical uses Iloperidone is indicated for the treatment of schizophrenia. In a 2013 study in a comparison o ...

(HP-873, ILO-522; Fanapt, Fiapta, Zomaril) – atypical antipsychotic / 5-HT_2A, 5-HT₆, 5-HT₇, D₂, D₃, D₄, and α₁-adrenergic receptor antagonis

* Midomafetamine, MDMA (Midomafetamine, 3,4-methylenedioxymethamphetamine, "ecstasy") –

serotonin–norepinephrine–dopamine releasing agent A serotonin–norepinephrine–dopamine releasing agent (SNDRA), also known as a triple releasing agent (TRA), is a type of drug which induces the release of serotonin, norepinephrine/epinephrine, and dopamine in the brain and body. SNDRAs produc ...

and 5-HT₁ and 5-HT₂ receptor agonist – specifically under development as an aid to

psychotherapy Psychotherapy (also psychological therapy, talk therapy, or talking therapy) is the use of psychological methods, particularly when based on regular personal interaction, to help a person change behavior, increase happiness, and overcome pro ...

for post-traumatic stress disorde

ref name="pmid27394687"> * NBTX-001 (

Xenon Xenon is a chemical element with the symbol Xe and atomic number 54. It is a dense, colorless, odorless noble gas found in Earth's atmosphere in trace amounts. Although generally unreactive, it can undergo a few chemical reactions such as the ...

) – NMDA receptor antagonis

*

Pomaglumetad methionil Pomaglumetad (LY-404,039) is an amino acid analog drug that acts as a highly selective agonist for the metabotropic glutamate receptor group II subtypes Metabotropic glutamate receptor 2, mGluR2 and Metabotropic glutamate receptor 3, mGluR3. Phar ...

(DB-103, LY-2140023) – mGluR₂ and mGluR₃ agonis

* Tianeptine oxalate/naloxone (TNX-601) – atypical

μ-opioid receptor The μ-opioid receptors (MOR) are a class of opioid receptors with a high affinity for enkephalins and beta-endorphin, but a low affinity for dynorphins. They are also referred to as μ(''mu'')-opioid peptide (MOP) receptors. The prototypical � ...

agonis

Social anxiety disorder

Fasedienol Fasedienol (; developmental code names PH94B and Aloradine), also known as 4-androstadienol or as 4,16-androstadien-3β-ol, is a pherine which is under development by VistaGen Therapeutics in a nasal spray formulation ( ''PRN'') for the acute trea ...

(Aloradine; PH94B; 4-androstadienol) – vomeropherine / neurosteroid

*

JNJ-42165279 JNJ-42165279 is a drug developed by Janssen Pharmaceutica which acts as a potent and selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH), with an IC50 of 70 nM. It is described as a covalently binding but slowly reversible se ...

– FAAH inhibitor *

sublingual (BHV-0223) – "

glutamate Glutamic acid (symbol Glu or E; the ionic form is known as glutamate) is an α-amino acid that is used by almost all living beings in the biosynthesis of proteins. It is a non-essential nutrient for humans, meaning that the human body can syn ...

modulator" / undefined mechanism of actio

* TGW00AA (FKW00GA) – 5-HT_1A receptor agonist, 5-HT_2A receptor antagonis

*

(EMD-68843, SB-659746A; Viibryd) – 5-HT_1A receptor partial agonist and serotonin reuptake inhibito

Others/unspecified

AVN-101 AVN-101, a close structural analogue of latrepirdine, is a selective 5-HT6 receptor antagonist which is under development by Avineuro Pharmaceuticals for the treatment of Alzheimer's disease and anxiety disorders. As of November 2013, it is i ...

– 5-HT₆ receptor antagonis

*

(IW-2143) – "GABA modulator" / undefined mechanism of action
*

– fatty acid amide hydrolase, FAAH inhibitor

* JNJ-61393215 – orexin OX₁ receptor antagonis

* MP-20X – CB₁ and 5-HT_1A receptor modulato

* SRX-246 –

vasopressin Human vasopressin, also called antidiuretic hormone (ADH), arginine vasopressin (AVP) or argipressin, is a hormone synthesized from the AVP gene as a peptide prohormone in neurons in the hypothalamus, and is converted to AVP. It then travel ...

V_1A receptor antagonis

References

External links

AdisInsight – Springer

2016 Medicines in Development for Mental Health - PhRMA
{{Anxiolytics Anxiolytics Anxiolytics, investigational Experimental drugs