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4-Methylhistamine
4-Methylhistamine is a histamine agonist A histamine agonist is a drug which causes increased activity at one or more of the four histamine receptor subtypes. H2: Betazole and Impromidine are examples of agonists used in diagnostics to increase histamine. H3: Betahistine is a weak Hi ... selective for the H4 subtype. References {{DEFAULTSORT:Methylhistamine, 4- Amines Imidazoles ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Histamine H4 Receptor
The histamine H4 receptor, like the other three histamine receptors, is a member of the G protein-coupled receptor superfamily that in humans is encoded by the ''HRH4'' gene. Discovery Unlike the histamine receptors discovered earlier, H4 was found in 2000 through a search of the human genomic DNA data base. Tissue distribution H4 is highly expressed in bone marrow and white blood cells and regulates neutrophil release from bone marrow and subsequent infiltration in the zymosan-induced pleurisy mouse model. It was also found that H4R exhibits a uniform expression pattern in the human oral epithelium. Function The Histamine H4 receptor has been shown to be involved in mediating eosinophil shape change and mast cell chemotaxis. This occurs via the βγ subunit acting at phospholipase C to cause actin polymerization and eventually chemotaxis. Structure The 3D structure of the H4 receptor has not been solved yet due to the difficulties of GPCR crystallization. Some attempts have ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Histamine Agonist
A histamine agonist is a drug which causes increased activity at one or more of the four histamine receptor subtypes. H2: Betazole and Impromidine are examples of agonists used in diagnostics to increase histamine. H3: Betahistine is a weak Histamine1 agonist and a very strong Histamine3 antagonist (paradoxically histamine increasing). See also * Histamine antagonist Antihistamines are drugs which treat allergic rhinitis, common cold, influenza, and other allergies. Typically, people take antihistamines as an inexpensive, generic (not patented) drug that can be bought without a prescription and provides re ... External links * * {{pharmacology-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amines
In chemistry, amines (, ) are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines). Important amines include amino acids, biogenic amines, trimethylamine, and aniline; Inorganic derivatives of ammonia are also called amines, such as monochloramine (). The substituent is called an amino group. Compounds with a nitrogen atom attached to a carbonyl group, thus having the structure , are called amides and have different chemical properties from amines. Classification of amines Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
