3CLpro-1
3CLpro-1 is an antiviral drug related to rupintrivir which acts as a 3CL protease inhibitor and was originally developed for the treatment of human enterovirus 71. It is one of the most potent of a large series of compounds developed as inhibitors of the viral enzyme 3CL protease, with an ''in vitro'' IC50 of 200  nM. It also shows activity against coronavirus diseases such as SARS and MERS, and is under investigation as a potential treatment agent for the viral disease COVID-19. See also * Carmofur * Ebselen * GC376 * GRL-0617 * Rupintrivir * Theaflavin digallate Theaflavin digallate (TFDG) is an antioxidant natural phenol found in black tea, and a theaflavin derivative. Health * TFDG is a scavenger of superoxide ''in vitro'', even more so than EGCG. * Tea polyphenols including TFDG reduce angiogenesis, ... References Antiviral drugs SARS-CoV-2 main protease inhibitors {{antiinfective-drug-stub ...
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