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2C-I-NBOMe
25I-NBOMe (2C-I-NBOMe, Cimbi-5, Smiles and also shortened to "25I") is a synthetic hallucinogen that is used in biochemistry research for mapping the brain's usage of the type 2A serotonin receptor; it is also sometimes used for recreational purposes. A derivative of the substituted phenethylamine 2C-I family, it is the most well-known member of the 25-NB family. It was discovered in 2003 by chemist Ralf Heim at the Free University of Berlin, who published his findings in his PhD dissertation. The compound was subsequently investigated by a team at Purdue University led by David Nichols. The carbon-11 labelled version of 25I-NBOMe, 1C/sup>Cimbi-5, was synthesized and validated as a radiotracer for positron emission tomography (PET) in Copenhagen. Being the first 5-HT2A receptor full agonist PET radioligand, 1C/sup>-CIMBI-5 shows promise as a more functional marker of these receptors, particularly in their high affinity states. Street and media nicknames for this drug ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
25-NB Family
The 25-NB (25''x''-NB''x'') series, sometimes alternatively referred to as the NBOMe compounds, is a family of serotonergic psychedelics. They are substituted phenethylamines and were derived from the 2C family. They act as selective agonists of the serotonin 5-HT2A receptor. The 25-NB family is unique relative to other classes of psychedelics in that they are, generally speaking, extremely potent and relatively selective for the 5-HT2A receptor. Use of NBOMe series drugs has caused many deaths and hospitalisations since the drugs popularisation in the 2010s. This is primarily due to their high overdose potential and sellers passing off the compounds in the series as LSD. Chemical structure The 25-NB compounds are mostly ''N''-benzylphenethylamines, though in some cases the phenyl ring of the N-benzyl group is replaced by other heterocycles such as thiophene, pyridine, furan, tetrahydrofuran, benzodioxole or naphthalene, among others. Generally speaking, they have methoxy grou ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lysergic Acid Diethylamide
Lysergic acid diethylamide (LSD), also known colloquially as acid, is a potent psychedelic drug. Effects typically include intensified thoughts, emotions, and sensory perception. At sufficiently high dosages LSD manifests primarily mental, visual, as well as auditory, hallucinations. Dilated pupils, increased blood pressure, and increased body temperature are typical. Effects typically begin within half an hour and can last for up to 20 hours. LSD is also capable of causing mystical experiences and ego dissolution. It is used mainly as a recreational drug or for spiritual reasons. LSD is both the prototypical psychedelic and one of the "classical" psychedelics, being the psychedelics with the greatest scientific and cultural significance. LSD is typically either swallowed or held under the tongue. It is most often sold on blotter paper and less commonly as tablets, in a watery solution or in gelatin squares called panes. LSD is considered to be non-addictive with low potent ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2C-I
2C-I is a psychedelic phenethylamine of the 2C family. It was first synthesized by Alexander Shulgin and described in his 1991 book '' PiHKAL'' (''Phenethylamines I Have Known and Loved''). The drug has been used recreationally as psychedelic and other reported effects and was sometimes confused with the more potent chemical cousin 25I-NBOMe, nicknamed "Smiles," in the media.Weiss, Piper (September 20, 2012)2C-I or 'Smiles': The New Killer Drug Every Parent Should Know About.''Yahoo! News''Mackin, Teresa (October 9, 2012)Dangerous synthetic drug making its way across the country. WISH-TV Recreational use In the early 2000s, 2C-I was sold in Dutch smart shops after the drug 2C-B was banned. According to the US Drug Enforcement Administration, 2C-I is taken orally or snorted in a powder form.Reuters (March 20, 2011)Synthetic drug, subject of proposed bans, kill teen./ref> Drug prohibition laws European Union In December 2003, the European Council issued a binding order compe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Buccal Administration
Buccal administration is a topical route of administration by which drugs held or applied in the buccal () area (in the cheek) diffuse through the oral mucosa ( tissues which line the mouth) and enter directly into the bloodstream. Buccal administration may provide better bioavailability of some drugs and a more rapid onset of action compared to oral administration because the medication does not pass through the digestive system and thereby avoids first pass metabolism. As of May 2014, the psychiatric drug asenapine; the opioid drugs buprenorphine, naloxone, and fentanyl; the cardiovascular drug nitroglycerin; the nausea medication prochlorperazine; the hormone replacement therapy testosterone; and nicotine as a smoking cessation aid were commercially available in buccal forms, as was midazolam, an anticonvulsant, used to treat acute epileptic seizures. Buccal administration of vaccines has been studied, but there are challenges to this approach due to immune tolerance mechanis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Isotopes Of Carbon
Carbon (6C) has 15 known isotopes, from to , of which and are stable nuclide, stable. The longest-lived radionuclide, radioisotope is , with a half-life of years. This is also the only carbon radioisotope found in nature—trace quantities are formed cosmogenic nuclide, cosmogenically by the reaction + → + . The most stable artificial radioisotope is , which has a half-life of . All other radioisotopes have half-lives under 20 seconds, most less than 200 milliseconds. The least stable isotope is , with a half-life of . List of isotopes , - , , style="text-align:right" , 6 , style="text-align:right" , 2 , , [] , proton emission, 2p , Subsequently decays by double proton emission to for a net reaction of → + 4 , 0+ , , , - , rowspan=3, , rowspan=3 style="text-align:right" , 6 , rowspan=3 style="text-align:right" , 3 , rowspan=3, , rowspan=3, , β+ () , , rowspan=3, 3/2− , rowspan=3, , rowspan=3, , - , β+α () , Immediately decays ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tachycardia
Tachycardia, also called tachyarrhythmia, is a heart rate that exceeds the normal resting rate. In general, a resting heart rate over 100 beats per minute is accepted as tachycardia in adults. Heart rates above the resting rate may be normal (such as with exercise) or abnormal (such as with electrical problems within the heart). Complications Tachycardia can lead to fainting. When the rate of blood flow becomes too rapid, or fast blood flow passes on damaged endothelium, it increases the friction within vessels resulting in turbulence and other disturbances. According to the Virchow's triad, this is one of the three conditions that can lead to thrombosis (i.e., blood clots within vessels). Causes Some causes of tachycardia include: * Adrenergic storm * Anaemia * Anxiety * Atrial fibrillation * Atrial flutter * Atrial tachycardia * Atrioventricular reentrant tachycardia * AV nodal reentrant tachycardia * Brugada syndrome * Circulatory shock and its various causes ( obstr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Analytical Balance
An analytical balance (or chemical ''balance'') is a class of balance designed to measure small mass in the sub-milligram range. The measuring pan of an analytical balance (0.1 mg resolution or better) is inside a transparent enclosure with doors so that dust does not collect and so any air currents in the room do not affect the balance's operation. This enclosure is often called a draft shield. The use of a mechanically vented balance safety enclosure, which has uniquely designed acrylic airfoils, allows a smooth turbulence-free airflow that prevents balance fluctuation and the measure of mass down to 1 μg without fluctuations or loss of product. Also, the sample must be at room temperature to prevent natural convection from forming air currents inside the enclosure from causing an error in reading. Single pan mechanical substitution balance is a method of maintaining consistent response throughout the useful capacity of the balance. This is achieved by maintaining a constant ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Erowid
Erowid, also called Erowid Center, is a non-profit educational organization that provides information about psychoactive plants and chemicals. Erowid documents legal and illegal substances, including their intended and adverse effects. Information on Erowid's website is gathered from diverse sources including published literature, experts in related fields, and the experiences of the general public. Erowid acts as a publisher of new information as well as a library for the collection of documents and images published elsewhere. History Erowid was founded in April 1995 as a small business; their website appeared six months later. The name "Erowid" was chosen to reflect the organization's stated philosophy of education. Using Proto-Indo-European linguistic roots, "Erowid" roughly translates into "Earth Wisdom" (''er'' meaning 'earth,' 'exist,' and 'be born' and ''wid'' meaning 'knowledge' / 'wisdom' or 'to see').Emily Witt"The trip planners."''New Yorker.'' 23 November 2015. Ret ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Microgram
In the metric system, a microgram or microgramme is a unit of mass equal to one millionth () of a gram. The unit symbol is μg according to the International System of Units (SI); the recommended symbol in the United States and United Kingdom when communicating medical information is mcg. In μg the prefix symbol for micro- is the Greek letter μ (mu). Abbreviation and symbol confusion When the Greek lowercase "μ" (mu) in the symbol μg is typographically unavailable, it is occasionally – although not properly – replaced by the Latin lowercase "u". The United States-based Institute for Safe Medication Practices (ISMP) and the U.S. Food and Drug Administration (FDA) recommend that the symbol μg should not be used when communicating medical information due to the risk that the prefix μ (micro-) might be misread as the prefix m (milli-), resulting in a thousandfold overdose. The ISMP recommends the non- SI symbol mcg instead. However, the abbreviation mcg is also the sym ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Blotting Paper
Blotting paper, called bibulous paper, is a highly absorbent type of paper or other material. It is used to absorb an excess of liquid substances (such as ink or oil) from the surface of writing paper or objects. Blotting paper referred to as bibulous paper is mainly used in microscopy to remove excess liquids from the slide before viewing. Blotting paper has also been sold as a cosmetic to aid in the removal of skin oils and makeup. Manufacture Blotting paper is made from different materials of varying thickness, softness, etc. depending on the application. It is often made of cotton and manufactured on special paper machines. Blotting paper is reputed to be first referred to in the English language in the 15th century but there is a tradition in Norfolk, England that it was invented by accident at Lyng Mill on the River Wensum. It is reported that a Berkshire (England) paper mill worker failed to add sizing to a batch of paper that was being produced. The batch was discarde ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Intranasal
Nasal administration, popularly known as snorting, is a route of administration in which drugs are insufflated through the nose. It can be a form of either topical administration or systemic administration, as the drugs thus locally delivered can go on to have either purely local or systemic effects. Nasal sprays are locally acting drugs such as decongestants for cold and allergy treatment, whose systemic effects are usually minimal. Examples of systemically active drugs available as nasal sprays are migraine drugs, rescue medications for overdose and seizure emergencies, nicotine replacement, and hormone treatments. Advantages with nasal systemic drug delivery The nasal cavity is covered by a thin mucosa which is well vascularised. Therefore, a drug molecule can be transferred quickly across the single epithelial cell layer directly to the systemic blood circulation without first-pass hepatic and intestinal metabolism. The effect is often reached within 5 min for smaller ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Buccal Administration
Buccal administration is a topical route of administration by which drugs held or applied in the buccal () area (in the cheek) diffuse through the oral mucosa ( tissues which line the mouth) and enter directly into the bloodstream. Buccal administration may provide better bioavailability of some drugs and a more rapid onset of action compared to oral administration because the medication does not pass through the digestive system and thereby avoids first pass metabolism. As of May 2014, the psychiatric drug asenapine; the opioid drugs buprenorphine, naloxone, and fentanyl; the cardiovascular drug nitroglycerin; the nausea medication prochlorperazine; the hormone replacement therapy testosterone; and nicotine as a smoking cessation aid were commercially available in buccal forms, as was midazolam, an anticonvulsant, used to treat acute epileptic seizures. Buccal administration of vaccines has been studied, but there are challenges to this approach due to immune tolerance mechanis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
