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206P Barnard–Boattini
6P or 6-P may refer to: *6P, IATA code for Club Air *6P/d'Arrest, a periodic comet *6-P, abbreviation for 6-phosphate ** Mannose 6-phosphate ** Mannose 6-phosphate receptor ** Glucose 6-phosphate ** Glucose-6-phosphate dehydrogenase *F9F-6P, a model of Grumman F-9 Cougar *6P, former abbreviation for LMS Patriot Class, and a Classification of steam locomotives by British Railways, denoting a locomotive rated for Passenger trains *6P, NASA code for Progress M1-7 *6p, an arm of Chromosome 6 (human) * Nexus 6P, a smartphone manufactured by Huawei *Renault 6P, an aircraft engine designed by Renault in the 1920s *6P, the production code for the 1984 ''Doctor Who'' serial '' Resurrection of the Daleks'' *6, P, the citation form of Perri 6 See also * P6 (other) *PPPPPP (other) PPPPPP, Pppppp, or pppppp may refer to: * ''PPPPPP'' (manga), a manga series serialized in ''Weekly Shōnen Jump'' in 2021 * '' PPPPPP'', the soundtrack of the video game ''VVVVVV'' * '' Ppppp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Club Air
Club Air was an airline based in Verona, Italy operating domestic flights within Italy and international flights to Albania, France, Moldova, Kosovo, Romania and Ukraine. It had a hub at Verona Airport. History The airline was originally established in October 2002 with its first flights the next month. The Italian civil aviation authority, ENAC, withdrew the airlines operating certificate on 12 December 2006. Services resumed under new owners and new management on May 2, 2007. This new venture was unsuccessful with operations ceasing in May 2008. Destinations The airline offered a combination of domestic services and services to Eastern Europe, trying to take advantage of migrant workers travelling to and from their countries of origin. Routes included those from Verona to Bucharest, Timișoara Bacău, Cluj-Napoca (Romania), Chişinău (Moldova), Pristina (Kosovo) Lviv (Ukraine) . Fleet See also * List of defunct airlines of Italy This is a list of defunct airline ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
6P/d'Arrest
6P/d'Arrest (also known as d'Arrest's Comet or Comet d'Arrest) is a periodic Jupiter-family comet in the Solar System, orbiting between Mars and Jupiter. It passed from the Earth on August 12, 1976. The most recent perihelion passage took place on September 17, 2021, when the comet had a solar elongation of 95 degrees at approximately apparent magnitude of 10. The comet last came to perihelion (closest approach to the Sun) on March 2, 2015, but it was in an unfavorable apparition as it had a solar elongation of less than 30 degrees from October 2014 until May 2015. In 1991, Andrea Carusi and Giovanni B. Valsecchi ( Istituto Astrofisica Spaziale, Rome), and Ľubor Kresák and Margita Kresáková ( Slovak Astronomical Institute, Bratislava) independently suggested this comet was the same as a comet observed by Philippe de La Hire in 1678. It was first observed by Heinrich Ludwig d'Arrest, in Leipzig, Germany, on 28th and 30 June 1851. The comet nucleus is estimated ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mannose 6-phosphate
Mannose-6-phosphate (M6P) is a molecule bound by lectin in the immune system. M6P is converted to fructose 6-phosphate by mannose phosphate isomerase. M6P is a key targeting signal for acid hydrolase precursor proteins that are destined for transport to lysosomes. The M6P tag is added to such proteins in the ''cis''-Golgi apparatus. Specifically, in a reaction involving uridine diphosphate (UDP) and ''N''-acetylglucosamine, the enzyme N-acetylglucosamine-1-phosphate transferase catalyzes the ''N''-linked glycosylation of asparagine residues with M6P. Once appropriately marked with the M6P targeting signal, these proteins are moved to the ''trans''-Golgi network. There, the M6P moiety is recognized and bound by mannose 6-phosphate receptor (MPR) proteins at pH 6.5–6.7. The M6P-tagged lysosomal enzymes are shipped to the late endosomes via vesicular transport. Enzyme replacement therapy (ERT) for several lysosomal storage diseases relies on this pathway to efficiently direct syn ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mannose 6-phosphate Receptor
The mannose 6-phosphate receptors (MPRs) are transmembrane glycoproteins that target enzymes to lysosomes in vertebrates. Mannose 6-phosphate receptors bind newly synthesized lysosomal hydrolases in the trans-Golgi network (TGN) and deliver them to pre-lysosomal compartments. There are two different MPRs, one of ~300kDa and a smaller, dimeric receptor of ~46kDa. The larger receptor is known as the cation-independent mannose 6-phosphate receptor ( CI-MPR), while the smaller receptor ( CD-MPR) requires divalent cations to efficiently recognize lysosomal hydrolases. While divalent cations are not essential for ligand binding by the human CD-MPR, the nomenclature has been retained. Both of these receptors bind terminal mannose 6-phosphate with similar affinity (CI-MPR = 7 μM, CD-MPR = 8 μM) and have similar signals in their cytoplasmic domains for intracellular trafficking. History Elizabeth Neufeld was studying patients who had multiple inclusion bodies present in their ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glucose 6-phosphate
Glucose 6-phosphate (G6P, sometimes called the Robison ester) is a glucose sugar phosphorylated at the hydroxy group on carbon 6. This dianion is very common in cells as the majority of glucose entering a cell will become phosphorylated in this way. Because of its prominent position in cellular chemistry, glucose 6-phosphate has many possible fates within the cell. It lies at the start of two major metabolic pathways: glycolysis and the pentose phosphate pathway. In addition to these two metabolic pathways, glucose 6-phosphate may also be converted to glycogen or starch for storage. This storage is in the liver and muscles in the form of glycogen for most multicellular animals, and in intracellular starch or glycogen granules for most other organisms. Production From glucose Within a cell, glucose 6-phosphate is produced by phosphorylation of glucose on the sixth carbon. This is catalyzed by the enzyme hexokinase in most cells, and, in higher animals, glucokinase in certain ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glucose-6-phosphate Dehydrogenase
Glucose-6-phosphate dehydrogenase (G6PD or G6PDH) () is a cytosolic enzyme that catalyzes the chemical reaction : D-glucose 6-phosphate + NADP+ + H2O 6-phospho-D-glucono-1,5-lactone + NADPH + H+ This enzyme participates in the pentose phosphate pathway (see image), a metabolic pathway that supplies reducing energy to cells (such as erythrocytes) by maintaining the level of the co-enzyme nicotinamide adenine dinucleotide phosphate (NADPH). The NADPH in turn maintains the level of glutathione in these cells that helps protect the red blood cells against oxidative damage from compounds like hydrogen peroxide. Of greater quantitative importance is the production of NADPH for tissues involved in biosynthesis of fatty acids or isoprenoids, such as the liver, mammary glands, adipose tissue, and the adrenal glands. G6PD reduces NADP+ to NADPH while oxidizing glucose-6-phosphate. Glucose-6-phosphate dehydrogenase is also an enzyme in the Entner–Doudoroff pathway, a type of glycolysis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Grumman F-9 Cougar
The Grumman F9F/F-9 Cougar is a carrier-based fighter aircraft for the United States Navy and United States Marine Corps. Based on Grumman's earlier F9F Panther, the Cougar replaced the Panther's straight wing with a more modern swept wing. Thrust was also increased with the installation of a newer, more powerful engine. The Navy considered the Cougar an updated version of the Panther, despite having a different official name, and thus Cougars started off from F9F-6. Design and development Early development Rumors that the Soviet Union had produced a swept-wing fighter had circulated a year before the Mikoyan-Gurevich MiG-15 first appeared at air shows in 1949. Despite the level of activity taking place with swept-wing aircraft, the Navy was not initially focused on the development of such aircraft. This was largely because the Navy's focus at the time was defending the battle group against high speed, high altitude bombers with interceptors, as well as escorting medium-rang ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
LMS Patriot Class
The Patriot Class was a class of 52 express passenger steam locomotives built for the London Midland and Scottish Railway. The first locomotive of the class was built in 1930 and the last in 1934. The class was based on the chassis of the Royal Scot combined with the boiler from Large Claughtons earning them the nickname ''Baby Scots''. A total of 18 were rebuilt to create the LMS Rebuilt Patriot Class between 1946 and 1948; thereafter those not subjected to rebuilding were often referred to as the Unrebuilt Patriot Class. These remaining 34 unrebuilt engines were withdrawn between 1960 and 1962. Overview The first two were rebuilt in 1930 from the 1912-built LNWR Large Claughton Class, retaining the original driving wheels with their large bosses, the "double radial" bogie truck and some other parts. Of the subsequent 50 locomotives of the class 40 were nominal rebuilds of Claughtons, being in fact new builds classified as rebuilt engines so that they could be charged t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Steam Locomotives Of British Railways
The steam locomotives of British Railways were used by British Railways over the period 1948–1968. The vast majority of these were inherited from its four constituent companies, the " Big Four". In addition, BR built 2,537 steam locomotives in the period 1948–1960, 1,538 to pre-nationalisation designs and 999 to its own standard designs. These locomotives had short working lives, some as little as five years, because of the decision to end the use of steam traction by 1968, against a design life of over 30 years and a theoretical final withdrawal date of between 1990 and 2000. Background British Railways was created on 1 January 1948 principally by the merger of the " Big Four" grouped railway companies: the Great Western Railway (GWR), the London, Midland and Scottish Railway (LMS), the London and North Eastern Railway (LNER) and the Southern Railway (SR). It inherited a wide legacy of locomotives and rolling stock, much of which needed replacing due to the ravages of Wor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Progress M1-7
Progress M1-7, identified by NASA as Progress 6P, was a Progress spacecraft used to resupply the International Space Station. It was a Progress-M1 11F615A55 spacecraft, with the serial number 256. Launch Progress M1-7 was launched by a Soyuz-FG carrier rocket from Site 1/5 at the Baikonur Cosmodrome. Launch occurred at 18:24:12 UTC on 26 November 2001. The spacecraft docked with the aft port of the '' Zvezda'' module at 19:43:02 UTC on 28 November. It was unable to establish a hard dock due to debris from Progress M-45 on the docking port, which had to be removed in an unscheduled extra-vehicular activity on 3 December 2001, after which it was able to establish a hard dock. Docking Progress M1-7 remained docked to the ISS for 112 days before undocking at 17:43 UTC on 19 March 2002 to make way for Progress M1-8. It was deorbited at 01:27 UTC on 20 March 2002. The spacecraft burned up in the atmosphere over the Pacific Ocean, with any remaining debris landing in the ocean at ar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chromosome 6 (human)
Chromosome 6 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 6 spans more than 170 million base pairs (the building material of DNA) and represents between 5.5 and 6% of the total DNA in cells. It contains the major histocompatibility complex, which contains over 100 genes related to the immune response, and plays a vital role in organ transplantation. Genes The human leukocyte antigen lies on chromosome 6, with the exception of the gene for β2-microglobulin (which is located on chromosome 15), and encodes cell-surface antigen-presenting proteins among other functions. Number of genes In 2003, the entirety of chromosome 6 was manually annotated for proteins, resulting in the identification of 1,557 genes, and 633 pseudogenes. The following are some of the newer gene count estimates. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nexus 6P
Nexus 6P (codenamed ''Angler'') (also known as the Nexus 6 Plus, Nexus 6 Pro or Nexus 6 Premium) is an Android smartphone developed and marketed by Google and manufactured by Huawei. It succeeded the Nexus 6 as the flagship device of the Nexus line of Android devices by Google. Officially unveiled on 29 September 2015 along with the Nexus 5X at the Google Nexus 2015 press event held in San Francisco, it was made available for pre-order on the same day in United States, United Kingdom, Ireland, and Japan. Significant changes over previous Nexus devices include an all-aluminum based body that is thinner and lighter than the Nexus 6, a rear fingerprint reader called Nexus Imprint, a faster octa-core Snapdragon 810 v2.1 system-on-chip (SoC), an AMOLED display, better cameras, enhanced LTE connectivity, a reversible USB-C dock connector, and the removal of wireless charging. The Nexus 6P was also the first Nexus device to be available with 128GB of internal storage, as well as the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
_(cropped).jpg "Click for more on -> Nexus 6P")