|
2008 Chinese Heparin Adulteration
2008 Chinese heparin adulteration, refers to heparin adulteration incidents that occurred in the United States of America in 2008. Pharmaceutical company Baxter International subcontracted the creation of precursor chemicals of heparin to Scientific Protein Laboratories, an American company with production facilities located in China. Scientific Protein Laboratories then used counterfeit precursors to create the chemicals ordered. Baxter then sold this adulterated heparin in the US, which killed 81 people, and left 785 severely injured. This caught the attention of the media and the USA Food and Drug Administration leading to numerous ongoing lawsuits. Overview The raw material for the recalled heparin batches was processed in China from pig's intestines by the American pharmaceutical firm Scientific Protein Laboratories. The U.S. Food and Drug Administration was quoted as stating that at least 81 deaths were believed to be linked to a raw heparin ingredient imported from the P ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Heparin
Heparin, also known as unfractionated heparin (UFH), is a medication and naturally occurring glycosaminoglycan. Since heparins depend on the activity of antithrombin, they are considered anticoagulants. Specifically it is also used in the treatment of heart attacks and unstable angina. It is given intravenously or by injection under the skin. Other uses for its anticoagulant properties include inside blood specimen test tubes and kidney dialysis machines. Common side effects include bleeding, pain at the injection site, and low blood platelets. Serious side effects include heparin-induced thrombocytopenia. Greater care is needed in those with poor kidney function. Heparin is contraindicated for suspected cases of vaccine-induced pro-thrombotic immune thrombocytopenia (VIPIT) secondary to SARS-CoV-2 vaccination, as heparin may further increase the risk of bleeding in an anti-PF4/heparin complex autoimmune manner, in favor of alternative anticoagulant medications (such as arg ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chondroitin Sulfate
Chondroitin sulfate is a sulfated glycosaminoglycan (GAG) composed of a chain of alternating sugars ( N-acetylgalactosamine and glucuronic acid). It is usually found attached to proteins as part of a proteoglycan. A chondroitin chain can have over 100 individual sugars, each of which can be sulfated in variable positions and quantities. Chondroitin sulfate is an important structural component of cartilage, and provides much of its resistance to compression. Along with glucosamine, chondroitin sulfate has become a widely used dietary supplement for treatment of osteoarthritis, although large clinical trials failed to demonstrate any symptomatic benefit of chondroitin. Medical use Chondroitin is used in dietary supplements as an alternative medicine to treat osteoarthritis. It is also approved and regulated as a symptomatic slow-acting drug for this disease (SYSADOA) in Europe and some other countries. It is commonly sold together with glucosamine. A 2015 Cochrane review of clini ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adulteration
An adulterant is caused by the act of adulteration, a practice of secretly mixing a substance with another. Typical substances that are adulterated include but are not limited to food, cosmetics, pharmaceuticals, fuel, or other chemicals, that compromise the safety or effectiveness of the said substance. It will not normally be present in any specification or declared substances due to accident or negligence rather than intent, and also for the introduction of unwanted substances after the product has been made. Adulteration, therefore, implies that the adulterant was introduced deliberately in the initial manufacturing process, or sometimes that it was present in the raw materials and should have been removed, but was not. An adulterant is distinct from, for example, permitted food preservatives. There can be a fine line between adulterant and additive; chicory may be added to coffee to reduce the cost or achieve a desired flavor—this is adulteration if not declared, but m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drug Safety
Term Given By Tushar Sharma (UPES Batch 2025) Pharmacovigilance (PV, or PhV), also known as drug safety, is the pharmaceutical science relating to the "collection, detection, assessment, monitoring, and prevention" of adverse effects with pharmaceutical products. The etymological roots for the word "pharmacovigilance" are: (Greek for drug) and (Latin for to keep watch). As such, pharmacovigilance heavily focuses on adverse drug reactions (ADR), which are defined as any response to a drug which is noxious and unintended, including lack of efficacy (the condition that this definition only applies with the doses normally used for the prophylaxis, diagnosis or therapy of disease, or for the modification of physiological disorder function was excluded with the latest amendment of the applicable legislation). Medication errors such as overdose, and misuse and abuse of a drug as well as drug exposure during pregnancy and breastfeeding, are also of interest, even without an adverse ev ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Product Safety Scandals
Product may refer to: Business * Product (business), an item that serves as a solution to a specific consumer problem. * Product (project management), a deliverable or set of deliverables that contribute to a business solution Mathematics * Product (mathematics) Algebra * Direct product Set theory * Cartesian product of sets Group theory * Direct product of groups * Semidirect product * Product of group subsets * Wreath product * Free product * Zappa–Szép product (or knit product), a generalization of the direct and semidirect products Ring theory * Product of rings * Ideal operations, for product of ideal (ring theory)#Ideal operations, ideals Linear algebra * Scalar multiplication * Matrix multiplication * Inner product, on an inner product space * Exterior product or wedge product * Multiplication of vectors: ** Dot product ** Cross product ** Seven-dimensional cross product ** Triple product, in vector calculus * Tensor product Topology * Product topology Algebraic to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2008 Disasters In China
8 (eight) is the natural number following 7 and preceding 9. In mathematics 8 is: * a composite number, its proper divisors being , , and . It is twice 4 or four times 2. * a power of two, being 2 (two cubed), and is the first number of the form , being an integer greater than 1. * the first number which is neither prime nor semiprime. * the base of the octal number system, which is mostly used with computers. In octal, one digit represents three bits. In modern computers, a byte is a grouping of eight bits, also called an octet. * a Fibonacci number, being plus . The next Fibonacci number is . 8 is the only positive Fibonacci number, aside from 1, that is a perfect cube. * the only nonzero perfect power that is one less than another perfect power, by Mihăilescu's Theorem. * the order of the smallest non-abelian group all of whose subgroups are normal. * the dimension of the octonions and is the highest possible dimension of a normed division algebra. * the first numb ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical Scandals In China
Medicine is the science and practice of caring for a patient, managing the diagnosis, prognosis, prevention, treatment, palliation of their injury or disease, and promoting their health. Medicine encompasses a variety of health care practices evolved to maintain and restore health by the prevention and treatment of illness. Contemporary medicine applies biomedical sciences, biomedical research, genetics, and medical technology to diagnose, treat, and prevent injury and disease, typically through pharmaceuticals or surgery, but also through therapies as diverse as psychotherapy, external splints and traction, medical devices, biologics, and ionizing radiation, amongst others. Medicine has been practiced since prehistoric times, and for most of this time it was an art (an area of skill and knowledge), frequently having connections to the religious and philosophical beliefs of local culture. For example, a medicine man would apply herbs and say prayers for healing, or an ancie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Product Recalls
Product may refer to: Business * Product (business), an item that serves as a solution to a specific consumer problem. * Product (project management), a deliverable or set of deliverables that contribute to a business solution Mathematics * Product (mathematics) Algebra * Direct product Set theory * Cartesian product of sets Group theory * Direct product of groups * Semidirect product * Product of group subsets * Wreath product * Free product * Zappa–Szép product (or knit product), a generalization of the direct and semidirect products Ring theory * Product of rings * Ideal operations, for product of ideals Linear algebra * Scalar multiplication * Matrix multiplication * Inner product, on an inner product space * Exterior product or wedge product * Multiplication of vectors: ** Dot product ** Cross product ** Seven-dimensional cross product ** Triple product, in vector calculus * Tensor product Topology * Product topology Algebraic topology * Cap product * Cup product * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scandals In China
A scandal can be broadly defined as the strong social reactions of outrage, anger, or surprise, when accusations or rumours circulate or appear for some reason, regarding a person or persons who are perceived to have transgressed in some way. These reactions are usually noisy and may be conflicting, and they often have negative effects on the status and credibility of the person(s) or organisation involved. Society is scandalised when it becomes aware of breaches of moral norms or legal requirements, often when these have remained undiscovered or been concealed for some time. Such breaches have typically erupted from greed, lust or the abuse of power. Scandals may be regarded as political, sexual, moral, literary or artistic but often spread from one realm into another. The basis of a scandal may be factual or false, or a combination of both. In contemporary times, exposure of a scandalous situation is often made by mass media. Contemporary media has the capacity to sprea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
List Of Medicine Contamination Incidents
The following list encompasses notable medicine contamination and adulteration incidents. *1937 Elixir sulfanilamide incident: S. E. Massengill Company used diethylene glycol as the solvent for the antibacterial sulfanilamide, leading to the 1938 passage of the Federal Food, Drug, and Cosmetic Act. *1942, Nose droppers were found to be contaminated by users to the detriment of subsequent users. Bacterial growth was found in all ephedrine and neosynephrin solutions that were examined. *1970s-1985 Treatments for hemophilia derived from human blood were contaminated with HIV and hepatitis C and infected over 10,000 patients worldwide. The manufacturers of the affected products became aware of the contamination but continued to sell it. After the contaminated products were banned in many developed countries, sales were shifted to developing markets. *1982 Chicago Tylenol murders: Tylenol pain-relief capsules were laced with potassium cyanide, leading to seven deaths. *2007 Panamani ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arthritis
Arthritis is a term often used to mean any disorder that affects joints. Symptoms generally include joint pain and stiffness. Other symptoms may include redness, warmth, swelling, and decreased range of motion of the affected joints. In some types of arthritis, other organs are also affected. Onset can be gradual or sudden. There are over 100 types of arthritis. The most common forms are osteoarthritis (degenerative joint disease) and rheumatoid arthritis. Osteoarthritis usually occurs with age and affects the fingers, knees, and hips. Rheumatoid arthritis is an autoimmune disorder that often affects the hands and feet. Other types include gout, lupus, fibromyalgia, and septic arthritis. They are all types of rheumatic disease. Treatment may include resting the joint and alternating between applying ice and heat. Weight loss and exercise may also be useful. Recommended medications may depend on the form of arthritis. These may include pain medications such as ibuprofen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Time Magazine
''Time'' (stylized in all caps) is an American news magazine based in New York City. For nearly a century, it was published weekly, but starting in March 2020 it transitioned to every other week. It was first published in New York City on March 3, 1923, and for many years it was run by its influential co-founder, Henry Luce. A European edition (''Time Europe'', formerly known as ''Time Atlantic'') is published in London and also covers the Middle East, Africa, and, since 2003, Latin America. An Asian edition (''Time Asia'') is based in Hong Kong. The South Pacific edition, which covers Australia, New Zealand, and the Pacific Islands, is based in Sydney. Since 2018, ''Time'' has been published by Time USA, LLC, owned by Marc Benioff, who acquired it from Meredith Corporation. History ''Time'' has been based in New York City since its first issue published on March 3, 1923, by Briton Hadden and Henry Luce. It was the first weekly news magazine in the United States. The two ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
