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1977 Russian Flu
The 1977 Russian flu was an influenza pandemic that was first reported by the Soviet Union in 1977 and lasted until 1979. The outbreak in northern China started in May 1977, slightly earlier than that in the Soviet Union. The pandemic mostly affected population younger than 25 or 26 years of age, and resulted in approximately 700,000 deaths worldwide. It was caused by an H1N1 flu strain which highly resembled a virus strain circulating worldwide from 1946 to 1957. Genetic analysis and several unusual characteristics of the 1977 Russian flu have prompted many researchers to say that the virus was released to the public through a laboratory accident, or resulted from a live-vaccine trial escape. History of outbreak In May 1977, an outbreak of flu took place in northern China including Liaoning, Jilin and Tianjin. The strain was isolated and determined by Chinese researchers to be H1N1, which mostly affected students in middle and primary schools who lacked immunity to H1N1 virus ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Influenza
Influenza, commonly known as "the flu", is an infectious disease caused by influenza viruses. Symptoms range from mild to severe and often include fever, runny nose, sore throat, muscle pain, headache, coughing, and fatigue. These symptoms begin from one to four days after exposure to the virus (typically two days) and last for about 2–8 days. Diarrhea and vomiting can occur, particularly in children. Influenza may progress to pneumonia, which can be caused by the virus or by a subsequent bacterial infection. Other complications of infection include acute respiratory distress syndrome, meningitis, encephalitis, and worsening of pre-existing health problems such as asthma and cardiovascular disease. There are four types of influenza virus, termed influenza viruses A, B, C, and D. Aquatic birds are the primary source of Influenza A virus (IAV), which is also widespread in various mammals, including humans and pigs. Influenza B virus (IBV) and Influenza C virus (ICV) pri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Siberia
Siberia ( ; rus, Сибирь, r=Sibir', p=sʲɪˈbʲirʲ, a=Ru-Сибирь.ogg) is an extensive geographical region, constituting all of North Asia, from the Ural Mountains in the west to the Pacific Ocean in the east. It has been a part of Russia since the latter half of the 16th century, after the Russians conquered lands east of the Ural Mountains. Siberia is vast and sparsely populated, covering an area of over , but home to merely one-fifth of Russia's population. Novosibirsk, Krasnoyarsk and Omsk are the largest cities in the region. Because Siberia is a geographic and historic region and not a political entity, there is no single precise definition of its territorial borders. Traditionally, Siberia extends eastwards from the Ural Mountains to the Pacific Ocean, and includes most of the drainage basin of the Arctic Ocean. The river Yenisey divides Siberia into two parts, Western and Eastern. Siberia stretches southwards from the Arctic Ocean to the hills of north-ce ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Peter Palese
Peter Palese is a United States microbiologist and professor and chair of the Department of Microbiology at the Icahn School of Medicine at Mount Sinai in New York City, and an expert in the field of RNA viruses. Palese built "the first genetic maps for influenza A, B and C viruses, identified the function of several viral genes, ...defined the mechanism of neuraminidase inhibitors (which are now FDA-approved antivirals)" and "pioneered the field of reverse genetics for negative-strand RNA viruses". Furtherance of this technique has been used by Palese and his colleagues in reconstructing and studying the pathogenicity of the extinct but deadly 1918 pandemic influenza virus. Reverse genetics also assist in the development of new flu vaccines. Palese is the author of multiple book chapters and more than 400 scientific publications. He is on the editorial board for Proceedings of the National Academy of Sciences of the United States of America (PNAS). He has been awarded mul ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vaccine Challenge Trial
A human challenge study, also called a challenge trial or controlled human infection model (CHIM), is a type of clinical trial for a vaccine or other pharmaceutical involving the intentional exposure of the test subject to the condition tested. Human challenge studies may be ethically controversial because they involve exposing test subjects to dangers beyond those posed by potential side effects of the substance being tested. During the mid 20th and 21st century, the number of human challenge studies has been increasing. A challenge study to test promising vaccines for prevention of COVID-19 was under consideration during 2020 by several vaccine developers, including the World Health Organization (WHO), and was approved in the UK in 2021. Over the second half of the 20th and the 21st centuries, vaccines for some 15 major pathogens have been fast-tracked in human challenge studies – involving about 30,000 participants – while contributing toward vaccine development to prevent ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vaccine Trial
A vaccine trial is a clinical trial that aims at establishing the safety and efficacy of a vaccine prior to it being licensed. A vaccine candidate drug is first identified through preclinical evaluations that could involve high throughput screening and selecting the proper antigen to invoke an immune response. Some vaccine trials may take months or years to complete, depending on the time required for the subjects to react to the vaccine and develop the required antibodies. Preclinical stage Preclinical development stages are necessary to determine the immunogenicity potential and safety profile for a vaccine candidate. This is also the stage in which the drug candidate may be first tested in laboratory animals prior to moving to the Phase I trials. Vaccines such as the oral polio vaccine have been first tested for adverse effects and immunogenicity in monkeys as well as non-human primates and lab mice. Recent scientific advances have helped to use transgenic animals as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1976 Swine Flu Outbreak
In 1976, an outbreak of the swine flu, influenza A virus subtype H1N1 at Fort Dix, New Jersey caused one death, hospitalized 13, and led to a mass immunization program. After the program began, the vaccine was associated with an increase in reports of Guillain–Barré syndrome (GBS), which can cause paralysis, respiratory arrest, and death. The immunization program was ended after approximately 25% of the population of the United States had been administered the vaccine. Richard Krause, director of the National Institute of Allergy and Infectious Diseases from 1975 to 1984, writes that the government response to the swine flu outbreak was considered to be too fast. The Centers for Disease Control and Prevention states, "Those who received the 1976 swine flu vaccine had a slight increased risk for developing GBS of approximately one additional case of GBS for every 100,000 people who got the swine flu vaccine." Chronology This chronology is heavily influenced by the official histo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anthropogenic Hazard
Anthropogenic hazards are hazards caused by human action or inaction. They are contrasted with natural hazards. Anthropogenic hazards may adversely affect humans, other organisms, biomes, and ecosystems. They can even cause an omnicide. The frequency and severity of hazards are key elements in some risk analysis methodologies. Hazards may also be described in relation to the impact that they have. A hazard only exists if there is a pathway to exposure. As an example, the center of the earth consists of molten material at very high temperatures which would be a severe hazard if contact was made with the core. However, there is no feasible way of making contact with the core, therefore the center of the earth currently poses no hazard. Anthropogenic hazards can be grouped into societal hazards (criminality, civil disorder, terrorism, war, industrial hazards, engineering hazards, power outage, fire), hazards caused by transportation and environmental hazards. Societal hazards ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Endemic (epidemiology)
In epidemiology, an infection is said to be endemic in a specific population or populated place when that infection is constantly maintained at a baseline level without extra infections being brought into the group as a result of travel or similar means. An endemic disease always has a steady, predictable number of people getting sick, but that number can be high (''hyperendemic'') or low (''hypoendemic''), and the disease can be severe or mild. Also, a disease that is usually endemic can become epidemic. For example, chickenpox is endemic (steady state) in the United Kingdom, but malaria is not. Every year, there are a few cases of malaria reported in the UK, but these do not lead to sustained transmission in the population due to the lack of a suitable vector (mosquitoes of the genus ''Anopheles''). Consequently, the number of people infected by malaria is too variable to be called endemic. However, the number of people who get chickenpox in the UK varies little from year ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Seasonal Flu
Flu season is an annually recurring time period characterized by the prevalence of an outbreak of influenza (flu). The season occurs during the cold half of the year in each hemisphere. It takes approximately two days to show symptoms. Influenza activity can sometimes be predicted and even tracked geographically. While the beginning of major flu activity in each season varies by location, in any specific location these minor epidemics usually take about three weeks to reach its pinnacle, and another three weeks to significantly diminish. Annually, about 3 to 5 million cases of severe illness and 290,000 to 650,000 deaths from seasonal flu occur worldwide. Cause Three virus families, Influenza virus A, B, and C are the main infective agents that cause influenza. During periods of cooler temperature, influenza cases increase roughly tenfold or more. Despite the higher incidence of manifestations of the flu during the season, the viruses are actually transmitted throughou ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
H3n2
Influenza A virus subtype H3N2 (A/H3N2) is a subtype of viruses that causes influenza (flu). H3N2 viruses can infect birds and mammals. In birds, humans, and pigs, the virus has mutated into many strains. In years in which H3N2 is the predominant strain, there are more hospitalizations. Classification H3N2 is a subtype of the viral genus Influenzavirus A, which is an important cause of human influenza. Its name derives from the forms of the two kinds of proteins on the surface of its coat, hemagglutinin (H) and neuraminidase (N). By reassortment, H3N2 exchanges genes for internal proteins with other influenza subtypes. Seasonal H3N2 flu Seasonal influenza kills an estimated 36,000 people in the United States each year. Flu vaccines are based on predicting which "mutants" of H1N1, H3N2, H1N2, and influenza B will proliferate in the next season. Separate vaccines are developed for the Northern and Southern Hemispheres in preparation for their annual epidemics. In the tropics, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Attack Rate
In epidemiology, the attack rate is the proportion of an at-risk population that contracts the disease during a specified time interval. It is used in hypothetical predictions and during actual outbreaks of disease. An at-risk population is defined as one that has no immunity to the attacking pathogen which can be either a novel pathogen or an established pathogen. It is used to project the number of infections to expect during an epidemic. This aids in marshalling resources for delivery of medical care as well as production of vaccines and/or anti-viral and anti-bacterial medicines.Anthony N. Glaser. High-Yield Biostatistics. Williams & Wilkins. Baltimore. 1995 The rate is arrived at by taking the number of new cases in the population at risk and dividing by the number of persons at risk in the population. See also *Incidence (epidemiology) *Compartmental models in epidemiology *Herd immunity Herd immunity (also called herd effect, community immunity, population immunity, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cheyenne, Wyoming
Cheyenne ( or ) is the capital and most populous city of the U.S. state of Wyoming, as well as the county seat of Laramie County, with 65,132 residents, per the 2020 US Census. It is the principal city of the Cheyenne metropolitan statistical area which encompasses all of Laramie County and had 100,512 residents as of the 2020 census. Local residents named the town for the Cheyenne Native American people in 1867 when it was founded in the Dakota Territory. Cheyenne is the northern terminus of the extensive Southern Rocky Mountain Front, which extends southward to Albuquerque, New Mexico, and includes the fast-growing Front Range Urban Corridor. Cheyenne is situated on Crow Creek and Dry Creek. History At a celebration on July 4, 1867, Grenville M. Dodge of the Union Pacific Railroad announced the selection of a townsite for its mountain region headquarters adjacent to the bridge the railroad planned to build across Crow Creek in the Territory of Dakota. At the sa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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