11-Hydroxyprogesterone

	11-Hydroxyprogesterone 11-Hydroxyprogesterone (11-OHP) may refer to: * 11α-Hydroxyprogesterone * 11β-Hydroxyprogesterone (21-deoxycorticosterone) See also * Hydroxyprogesterone * Deoxycorticosterone * Deoxycortisol Deoxycortisol may refer to: * 11-Deoxycortisol (cortodoxone, cortexolone, Reichstein's Substance; 17α,21-dihydroxyprogesterone) * 17-Deoxycortisol (corticosterone; 11β,21-dihydroxyprogesterone) * 21-Deoxycortisol (11β,17α-dihydroxyprogestero ... {{DEFAULTSORT:Hydroxyprogesterone, 11- Pregnanes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Deoxycorticosterone Deoxycorticosterone (DOC), or desoxycorticosterone, may refer to: * 11-Deoxycorticosterone (21-hydroxyprogesterone) * 21-Deoxycorticosterone (11β-hydroxyprogesterone) See also * Deoxycortisol * Deoxycortisone * 11-Hydroxyprogesterone {{Chemistry index Pregnanes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	11α-Hydroxyprogesterone 11α-Hydroxyprogesterone (11α-OHP), or 11α-hydroxypregn-4-ene-3,20-dione is an endogenous steroid and metabolite of progesterone. It is a weak antiandrogen, and is devoid of androgenic, estrogenic, and progestogenic activity. 11α-OHP was investigated as a topical antiandrogen for the treatment of androgen-dependent skin conditions in the early 1950s, and was found to produce some benefit. In 1995, 11α-OHP, along with its epimer 11β-hydroxyprogesterone, was identified as a very potent competitive inhibitor of both isoforms ( 1 and 2) of 11β-hydroxysteroid dehydrogenase (11β-HSD). It is notably not metabolized by 11β-HSD2. 11α-OHP is a more potent inhibitor of 11β-HSD than enoxolone (glycyrrhetinic acid) or carbenoxolone ''in vitro'' ( IC50 = 0.9 nM; IC50 = 5 nM in transfected cells). The compound has been found to be highly active in conferring mineralocorticoid sodium-retaining activity of corticosterone ''in vivo'' in rat bioassays and in increasing blood pressur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	11β-Hydroxyprogesterone 11β-Hydroxyprogesterone (11β-OHP), also known as 21-deoxycorticosterone, as well as 11β-hydroxypregn-4-ene-3,20-dione, is a naturally occurring, endogenous steroid and derivative of progesterone. It is a potent mineralocorticoid. Syntheses of 11β-OHP from progesterone is catalyzed by the steroid 11β-hydroxylase (CYP11B1) enzyme, and, to a lesser extent, by the aldosterone synthase enzyme (CYP11B2). Function Along with its epimer 11α-hydroxyprogesterone (11α-OHP), 11β-OHP has been identified as a very potent competitive inhibitor of both isoforms ( 1 and 2) of 11β-hydroxysteroid dehydrogenase (11β-HSD). Outcome of 21-hydroxylase deficiency It has been known since 1987 that increased levels of 11β-OHP occur in 21-hydroxylase deficiency. A study in 2017 has shown that in subjects with 21-hydroxylase deficiency, serum 11β-OHP concentrations range from 0.012 to 3.37 ng/mL, while in control group it was below detection limit of 0.012 ng/mL. 21-hydroxylase is an enzyme ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Deoxycortisol Deoxycortisol may refer to: * 11-Deoxycortisol (cortodoxone, cortexolone, Reichstein's Substance; 17α,21-dihydroxyprogesterone) * 17-Deoxycortisol (corticosterone; 11β,21-dihydroxyprogesterone) * 21-Deoxycortisol (11β,17α-dihydroxyprogesterone) See also * Cortisol (hydrocortisone) * Deoxycorticosterone Deoxycorticosterone (DOC), or desoxycorticosterone, may refer to: * 11-Deoxycorticosterone (21-hydroxyprogesterone) * 21-Deoxycorticosterone (11β-hydroxyprogesterone) See also * Deoxycortisol * Deoxycortisone * 11-Hydroxyprogesterone {{Che ... * Deoxycortisone {{chemistry index Pregnanes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]