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β-Methyl-2C-B
β-Methyl-2C-B (BMB) is a recreational designer drug with psychedelic effects. It is a structural isomer of DOB but is considerably less potent, having around half the potency of 2C-B itself with activity starting at a dosage of around 20 mg. It has two possible enantiomers but their activity has not been tested separately. See also * BOx (psychedelics) * βk-2C-B * BOB (psychedelic) * TCB-2 TCB-2 is a hallucinogen discovered in 2006 by Thomas McLean working in the lab of David Nichols at Purdue University. It is a conformationally-restricted derivative of the phenethylamine 2C-B, also a hallucinogen, and acts as a potent agonis ... * ZC-B References 2,5-Dimethoxyphenethylamines Designer drugs Psychedelic phenethylamines Serotonin receptor agonists {{Hallucinogen-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BOx (psychedelics)
BOx, also known as β-hydroxy- or -methoxy- and ring-substituted phenethylamines, are a group of psychedelic and other psychoactive drugs of the phenethylamine family. They have either a hydroxy group or methoxy group at the β position of the alkyl side chain as well as additional substitutions at the 2 through 5 positions of the phenyl ring. The BOx drugs were synthesized and tested by Alexander Shulgin and reported in his 1991 book ''PiHKAL'' (''Phenethylamines I Have Known and Loved''). List of BOx drugs The BOx drugs include the following, with their effects as reported by Shulgin also specified: * BOB (4-bromo-2,5,β-trimethoxyphenethylamine) – methoxy BOx analogue of 2C-B – altered state of consciousness, tinnitus, tingling, sense of awareness * BOH-2C-B (β-OH-2C-B) – hydroxy BOx analogue of 2C-B – encountered as a novel designer drug and presumably a psychedelic * BOD (4-methyl-2,5,β-trimethoxyphenethylamine) – methoxy BOx analogue of 2C-D – mild open-e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2,5-Dimethoxy-4-bromoamphetamine
Dimethoxybromoamphetamine (DOB), also known as brolamfetamine () and bromo-DMA, is a psychedelic drug and substituted amphetamine of the phenethylamine class of compounds. DOB was first synthesized by Alexander Shulgin in 1967. Its synthesis and effects are documented in Shulgin's book '' PiHKAL: A Chemical Love Story''. The drug acts as a serotonin 5-HT2 receptor agonist. Side effects Excessively high doses of DOB may cause diffuse arterial spasm. The vasospasm responded readily to intra-arterial and intravenous vasodilators, such as tolazoline. Interactions Pharmacology Pharmacodynamics DOB is a serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptor agonist. Its psychedelic effects are mediated by its agonistic properties at the 5-HT2A receptor. Due to its selectivity, DOB is often used in scientific research when studying the 5-HT2 receptor subfamily. It is a very weak agonist of the human trace amine-associated receptor 1 (TAAR1) and a weak agonist of the rhesus ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
βk-2C-B
βk-2C-B, or β-keto-2C-B, also known as 4-bromo-2,5-dimethoxy-β-ketophenylethylamine, is a novel psychedelic substance. It is the beta (β) ketone structural analogue of 2C-B, a psychedelic drug of the 2C family. It is used as a recreational drug, usually taken orally. βk-2C-B is a controlled substance in Canada, Germany, Switzerland, and the United Kingdom. History βk-2C-B is a designer drug, more specifically it is the beta keto analogue of the controlled substance 2C-B (2,5-dimethoxy-4-bromophenethylamine) which was first synthesized by Alexander Shulgin. It is unknown who first synthesized βk-2C-B, but it first appeared on the market mid-2013 as a recreational drug. Although a synthesis of the compound had previously been described, in the years after its emergence on the market, papers reporting analytical characterizations of the substance appeared. It is offered online and is termed a psychedelic drug. Since 12 October 2016, βk-2C-B has become a controlled substa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BOB (psychedelic)
BOB, also known as 4-bromo-2,5,β-trimethoxyphenethylamine, is a lesser-known psychedelic drug of the substituted phenethylamine, phenethylamine and BOx families. It is the β-methoxy group, methoxy analog (chemistry), analogue of 2C-B. BOB was first synthesized by Alexander Shulgin. In his book ''PiHKAL'', the dosage range is listed as 10 to 20mg, and the duration listed as 10 to 20hours. BOB produces an altered state of consciousness, tinnitus, a pleasant Paresthesia, tingling throughout the body, and a sense of awareness. Very little data exists about the pharmacological properties, metabolism, and toxicity of BOB. Legal status United Kingdom This substance is a Class A drug in the Drugs controlled by the UK Misuse of Drugs Act#Class A drugs, Drugs controlled by the UK Misuse of Drugs Act. See also * BOD (psychedelic), BOD * BOH (psychedelic), BOH * BOHD (psychedelic), BOHD * Bk-2C-B * β-Methyl-2C-B * 2C-B-aminorex * Phenethylamine External links BOB Entry at ''PiHKAL''· ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TCB-2
TCB-2 is a hallucinogen discovered in 2006 by Thomas McLean working in the lab of David Nichols at Purdue University. It is a conformationally-restricted derivative of the phenethylamine 2C-B, also a hallucinogen, and acts as a potent agonist for the 5-HT2A and 5-HT2C receptors with a Ki of 0.26nM at the human 5-HT2A receptor. In drug-substitution experiments in rats, TCB-2 was found to be of similar potency to both LSD and Bromo-DragonFLY, ranking it among the most potent phenethylamine hallucinogens yet discovered. This high potency and selectivity has made TCB-2 useful for distinguishing 5-HT2A receptor-mediated responses from those produced by other similar receptors. TCB-2 has similar but not identical effects in animals to related phenethylamine hallucinogens such as DOI, and has been used for studying how the function of the 5-HT2A receptor differs from that of other serotonin receptors in a number of animal models, such as studies of cocaine addiction and ne ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ZC-B
ZC-B (3-(4-bromo-2,5-dimethoxyphenyl)azetidine) is a phenethylamine derivative which acts as a serotonin receptor agonist selective for the 5-HT2 subtypes, with an EC50 of 1.6nM at 5-HT2A, vs 5.8nM at 5-HT2C. It is structurally related to the psychedelic phenethylamines 2C-B and DOB, but with the amine side chain conformationally restricted as an azetidine ring. See also * DOB * β-Methyl-2C-B * 4C-B * TCB-2 TCB-2 is a hallucinogen discovered in 2006 by Thomas McLean working in the lab of David Nichols at Purdue University. It is a conformationally-restricted derivative of the phenethylamine 2C-B, also a hallucinogen, and acts as a potent agonis ... * LPH-5 * LSZ References {{Phenethylamines 2,5-Dimethoxyphenethylamines Designer drugs Serotonin receptor agonists Azetidines Bromoarenes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Designer Drug
A designer drug is a structural or functional analog of a controlled substance that has been designed to mimic the pharmacological effects of the original drug, while avoiding classification as illegal and/or detection in standard drug tests. Designer drugs include psychoactive substances that have been designated by the European Union, Australia, and New Zealand, as new psychoactive substances (NPS) as well as analogs of performance-enhancing drugs such as designer steroids. Some of these designer drugs were originally synthesized by academic or industrial researchers in an effort to discover more potent derivatives with fewer side effects and shorter duration (and possibly also because it is easier to apply for patents for new molecules) and were later co-opted for recreational use. Other designer drugs were prepared for the first time in clandestine laboratories. Because the efficacy and safety of these substances have not been thoroughly evaluated in animal and human tr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Psychedelic
Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary mental states (known as psychedelic experiences or "trips") and a perceived "expansion of consciousness". Also referred to as classic hallucinogens or serotonergic hallucinogens, the term ''psychedelic'' is sometimes used more broadly to include various other types of hallucinogens as well, such as those which are atypical or adjacent to psychedelia like salvia and MDMA, respectively. Classic psychedelics generally cause specific psychological, visual, and auditory changes, and oftentimes a substantially altered state of consciousness. They have had the largest influence on science and culture, and include mescaline, LSD, psilocybin, and DMT. There are a large number of both naturally occurring and synthetic serotonergic psychedelics. Most psychedelic drugs fall into one of the three families of chemical compounds: tryptamines, phenethylamines, or lysergamides. They produce ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Structural Isomer
In chemistry, a structural isomer (or constitutional isomer in the IUPAC nomenclature) of a compound is a compound that contains the same number and type of atoms, but with a different connectivity (i.e. arrangement of bonds) between them. The term metamer was formerly used for the same concept. For example, butanol , methyl propyl ether , and diethyl ether have the same molecular formula but are three distinct structural isomers. The concept applies also to polyatomic ions with the same total charge. A classical example is the cyanate ion and the fulminate ion . It is also extended to ionic compounds, so that (for example) ammonium cyanate and urea are considered structural isomers,William F. Bynum, E. Janet Browne, Roy Porter (2014)''Dictionary of the History of Science'' page 218. and so are methylammonium formate and ammonium acetate . Structural isomerism is the most radical type of isomerism. It is opposed to stereoisomerism, in which the atoms and bon ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2C-B
2C-B, also known as 4-bromo-2,5-dimethoxyphenethylamine or by the slang name Nexus, is a synthetic psychedelic drug of the 2C family, mainly used as a recreational drug. It was first synthesized by Alexander Shulgin in 1974 for use in psychotherapy. To date, there is limited scientific information regarding the drug's pharmacokinetics and pharmacological effects in humans. The existing studies primarily classify 2C-B as a stimulant and hallucinogen, and less commonly an entactogen. 2C-B is also known by a number of slang names and appears on the illicit market in multiple forms: as a powder, in capsules or pills. For recreational use, the substance is generally consumed orally or nasally. Use Recreational 2C-B became briefly popular in the United States as substitute for the street drug ecstasy (MDMA) when the latter became illegal in 1985. Many 2C-B users are young adults who attend raves. Although 2C-B is still used in the rave subculture (commonly mistaken for and/o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enantiomer
In chemistry, an enantiomer (Help:IPA/English, /ɪˈnænti.əmər, ɛ-, -oʊ-/ Help:Pronunciation respelling key, ''ih-NAN-tee-ə-mər''), also known as an optical isomer, antipode, or optical antipode, is one of a pair of molecular entities which are mirror images of each other and non-superposable. Enantiomer molecules are like right and left hands: one cannot be superposed onto the other without first being converted to its mirror image. It is solely a relationship of chirality (chemistry), chirality and the permanent three-dimensional relationships among molecules or other chemical structures: no amount of re-orientation of a molecule as a whole or conformational isomerism, conformational change converts one chemical into its enantiomer. Chemical structures with chirality rotate plane-polarized light. A mixture of equal amounts of each enantiomer, a ''racemic mixture'' or a ''racemate'', does not rotate light. Stereoisomers include both enantiomers and diastereomers. Diaste ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
