Árpád Pusztai
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Árpád Pusztai
Árpád János Pusztai (8 September 1930 – 17 December 2021) was a Hungarian-born British biochemist and nutritionist who spent 36 years at the Rowett Research Institute in Aberdeen, Scotland. He was a world expert on plant lectins, authoring 270 papers and three books on the subject. In 1998, Árpád Pusztai publicly announced that the results of his research showed feeding genetically modified potatoes to rats had negative effects on their stomach lining and immune system. This led to scientific criticism. Pusztai was suspended and his annual contract was not renewed. The resulting controversy became known as the Pusztai affair. Life and career Pusztai was born in Budapest, Kingdom of Hungary (1920-1946), Hungary, on 8 September 1930. He was a student of the high school Óbudai Árpád Gimnázium and later obtained a diploma in chemistry in 1953 from the Eötvös Loránd University in Budapest. He worked for three years as an associate scientist at the Hungarian Academy of ...
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Biochemist
Biochemists are scientists who are trained in biochemistry. They study chemical processes and chemical transformations in living organisms. Biochemists study DNA, proteins and cell parts. The word "biochemist" is a portmanteau of "biological chemist." Biochemists also research how certain chemical reactions happen in cells and tissues and observe and record the effects of products in food additives and medicines. Biochemist researchers focus on playing and constructing research experiments, mainly for developing new products, updating existing products and analyzing said products. It is also the responsibility of a biochemist to present their research findings and create grant proposals to obtain funds for future research. Biochemists study aspects of the immune system, the expressions of genes, isolating, analyzing, and synthesizing different products, mutations that lead to cancers, and manage laboratory teams and monitor laboratory work. Biochemists also have to have ...
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Glycoproteins
Glycoproteins are proteins which contain oligosaccharide chains covalently attached to amino acid side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification. This process is known as glycosylation. Secreted extracellular proteins are often glycosylated. In proteins that have segments extending extracellularly, the extracellular segments are also often glycosylated. Glycoproteins are also often important integral membrane proteins, where they play a role in cell–cell interactions. It is important to distinguish endoplasmic reticulum-based glycosylation of the secretory system from reversible cytosolic-nuclear glycosylation. Glycoproteins of the cytosol and nucleus can be modified through the reversible addition of a single GlcNAc residue that is considered reciprocal to phosphorylation and the functions of these are likely to be an additional regulatory mechanism that controls phosphorylation-based signalling. In contrast, ...
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Royal Society Of Medicine
The Royal Society of Medicine (RSM) is a medical society in the United Kingdom, headquartered in London. History The Society was established in 1805 as Medical and Chirurgical Society of London, meeting in two rooms in barristers’ chambers at Gray's Inn and then moving to Lincoln's Inn Fields where it stayed for 25 years. In 1834 the Society moved to Berners Street and was granted a Royal Charter by King William IV. In 1889 under the leadership of Sir John MacAlister, a Building Committee chaired by Timothy Holmes supervised the move of the quarters of the Society from Berners Street to 20 Hanover Square. In 1905 an eleven-member committee headed by Sir Richard Douglas Powell organised the celebration of the Society's centenary. Two years later the Royal Medical and Chirurgical Society of London came together with seventeen specialist medical societies and, with a supplementary Royal Charter granted by Edward VII, became the Royal Society of Medicine. In 1910 the Societ ...
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Epithelium
Epithelium or epithelial tissue is one of the four basic types of animal tissue, along with connective tissue, muscle tissue and nervous tissue. It is a thin, continuous, protective layer of compactly packed cells with a little intercellular matrix. Epithelial tissues line the outer surfaces of organs and blood vessels throughout the body, as well as the inner surfaces of cavities in many internal organs. An example is the epidermis, the outermost layer of the skin. There are three principal shapes of epithelial cell: squamous (scaly), columnar, and cuboidal. These can be arranged in a singular layer of cells as simple epithelium, either squamous, columnar, or cuboidal, or in layers of two or more cells deep as stratified (layered), or ''compound'', either squamous, columnar or cuboidal. In some tissues, a layer of columnar cells may appear to be stratified due to the placement of the nuclei. This sort of tissue is called pseudostratified. All glands are made up of epit ...
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Statistical Significance
In statistical hypothesis testing, a result has statistical significance when it is very unlikely to have occurred given the null hypothesis (simply by chance alone). More precisely, a study's defined significance level, denoted by \alpha, is the probability of the study rejecting the null hypothesis, given that the null hypothesis is true; and the ''p''-value of a result, ''p'', is the probability of obtaining a result at least as extreme, given that the null hypothesis is true. The result is statistically significant, by the standards of the study, when p \le \alpha. The significance level for a study is chosen before data collection, and is typically set to 5% or much lower—depending on the field of study. In any experiment or observation that involves drawing a sample from a population, there is always the possibility that an observed effect would have occurred due to sampling error alone. But if the ''p''-value of an observed effect is less than (or equal to) the significa ...
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The Lancet
''The Lancet'' is a weekly peer-reviewed general medical journal and one of the oldest of its kind. It is also the world's highest-impact academic journal. It was founded in England in 1823. The journal publishes original research articles, review articles ("seminars" and "reviews"), editorials, book reviews, correspondence, as well as news features and case reports. ''The Lancet'' has been owned by Elsevier since 1991, and its editor-in-chief since 1995 has been Richard Horton. The journal has editorial offices in London, New York City, and Beijing. History ''The Lancet'' was founded in 1823 by Thomas Wakley, an English surgeon who named it after the surgical instrument called a lancet (scalpel). Members of the Wakley family retained editorship of the journal until 1908. In 1921, ''The Lancet'' was acquired by Hodder & Stoughton. Elsevier acquired ''The Lancet'' from Hodder & Stoughton in 1991. Impact According to the ''Journal Citation Reports'', the journal has a ...
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Media Frenzy
Media circus is a colloquial metaphor, or idiom, describing a news event for which the level of media coverage—measured by such factors as the number of reporters at the scene and the amount of material broadcast or published—is perceived to be excessive or out of proportion to the event being covered. Coverage that is Sensationalism, sensationalistic can add to the perception the event is the subject of a media circus. The term is meant to critique the coverage of the event by comparing it to the spectacle and pageantry of a circus. Usage of the term in this sense became common in the 1970s. It can also be called a media feeding frenzy or just media frenzy, especially when they cover the media coverage. History Although the idea is older, the term ''media circus'' began to appear around the mid-1970s. An early example is from the 1976 book by author Lynn Haney, in which she writes about a romance in which the athlete Chris Evert was involved: "Their courtship, after all, h ...
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World In Action
''World in Action'' was a British investigative current affairs programme made by Granada Television for ITV from 7 January 1963 until 7 December 1998. Its campaigning journalism frequently had a major impact on events of the day. Its production teams often took audacious risks, and the programme gained a solid reputation for its often unorthodox approach. The series was sold around the world and won numerous awards. In its heyday ''World in Action'' drew audiences of up to 23 million in Britain alone, equivalent to almost half the population. Cabinet ministers fell to its probings. Numerous innocent victims of the British criminal justice system, including the Birmingham Six, were released from jail. Honouring the programme in its 50th anniversary awards the Political Studies Association said, "''World in Action'' thrived on unveiling corruption and highlighting underhand dealings. ''World in Action'' came to be seen as hard-hitting investigative journalism at its best." ...
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Scientific Control
A scientific control is an experiment or observation designed to minimize the effects of variables other than the independent variable (i.e. confounding variables). This increases the reliability of the results, often through a comparison between control measurements and the other measurements. Scientific controls are a part of the scientific method. Controlled experiments Controls eliminate alternate explanations of experimental results, especially experimental errors and experimenter bias. Many controls are specific to the type of experiment being performed, as in the molecular markers used in SDS-PAGE experiments, and may simply have the purpose of ensuring that the equipment is working properly. The selection and use of proper controls to ensure that experimental results are valid (for example, absence of confounding variables) can be very difficult. Control measurements may also be used for other purposes: for example, a measurement of a microphone's background noise ...
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Snowdrop
''Galanthus'' (from Ancient Greek , (, "milk") + (, "flower")), or snowdrop, is a small genus of approximately 20 species of bulbous perennial herbaceous plants in the family Amaryllidaceae. The plants have two linear leaves and a single small white drooping bell-shaped flower with six petal-like (petaloid) tepals in two circles ( whorls). The smaller inner petals have green markings. Snowdrops have been known since the earliest times under various names, but were named ''Galanthus'' in 1753. As the number of recognised species increased, various attempts were made to divide the species into subgroups, usually on the basis of the pattern of the emerging leaves ( vernation). In the era of molecular phylogenetics this characteristic has been shown to be unreliable and now seven molecularly defined clades are recognised that correspond to the biogeographical distribution of species. New species continue to be discovered. Most species flower in winter, before the vernal equino ...
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Lectin
Lectins are carbohydrate-binding proteins that are highly specific for sugar groups that are part of other molecules, so cause agglutination of particular cells or precipitation of glycoconjugates and polysaccharides. Lectins have a role in recognition at the cellular and molecular level and play numerous roles in biological recognition phenomena involving cells, carbohydrates, and proteins. Lectins also mediate attachment and binding of bacteria, viruses, and fungi to their intended targets. Lectins are ubiquitous in nature and are found in many foods. Some foods, such as beans and grains, need to be cooked, fermented or sprouted to reduce lectin content. Some lectins are beneficial, such as CLEC11A, which promotes bone growth, while others may be powerful toxins such as ricin. Lectins may be disabled by specific mono- and oligosaccharides, which bind to ingested lectins from grains, legumes, nightshade plants, and dairy; binding can prevent their attachment to the carbohyd ...
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