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Crystal meth

Central nervous system stimulantPharmaceutical compoundBall-and-stick models of methamphetamine enantiomersClinical dataPronunciation(), (), () Trade namesDesoxyn, othersOther namesN-methylamphetamine, N,α-dimethylphenethylamine, desoxyephedrineAHFS/Drugs.comMonographPregnancycategoryAU: X (High risk)The system is developed for medicine that can be prescribed, but the equivalent is category X.DependenceliabilityPhysical: NonePsychological: Very highAddictionliabilityVery highRoutes ofadministrationBy mouth, intravenous, intramuscular, subcutaneous, inhalation, insufflation, rectal, vaginalDrug classStimulant;Serotonin–norepinephrine–dopamine releasing agentATC codeN06BA03 (WHO) Legal statusLegal statusAU: S8 (Controlled drug)BR: Class F2 (Prohibited psychotropics)CA: Schedule IDE: Anlage II (Authorized trade only, not prescriptible)NZ: Class AUK: Class AUS: Schedule IIUN: Psychotropic Schedule IIEU: Rx-onlySE: Förteckning IPharmacokinetic dataBioavailabilityOral: 67%Intranasal: 79%Inhalation: 67–90%Intravenous: 100%Protein bindingVaries widelyMetabolismCYP2D6 and FMO3Metabolites• Amphetamine • Pholedrine • N-Hydroxymethamphetamine • NorephedrineOnset of actionOral: 3 hours (peak)Intranasal: <15 minutesInhalation: <18 minutesIntravenous: <15 minutesElimination half-life9–12 hours (range 5–30 hours); irrespective of routeDuration of action8–12 hoursExcretionPrimarily kidneyIdentifiersIUPAC name(RS)-N-methyl-1-phenylpropan-2-amineCAS Number537-46-2(dl)-Methamphetamine hydrochloride: 300-42-5PubChemCID1206IUPHAR/BPS4803DrugBankDB01577ChemSpider1169UNII44RAL3456C(dl)-Methamphetamine hydrochloride: 24GNZ56D62KEGGD08187ChEBICHEBI:6809ChEMBLChEMBL1201201PDB ligandB40 (PDBe, RCSB PDB)CompTox Dashboard(EPA)DTXSID3043861ECHA InfoCard100.028.690 100.023.121, 100.028.690Chemical and physical dataFormulaC10H15NMolar mass149.237 g·mol3D model (JSmol)Interactive imageChiralityRacemic mixtureMelting point170 °C (338 °F) Boiling point212 °C (414 °F) at 760 mmHgSMILESCNC(C)Cc1ccccc1InChIInChI=1S/C10H15N/c1-9(11-2)8-10-6-4-3-5-7-10/h3-7,9,11H,8H2,1-2H3Key:MYWUZJCMWCOHBA-UHFFFAOYSA-N (verify)Methamphetamine is a central nervous system (CNS) stimulant that is primarily used as a recreational or performance-enhancing drug and less commonly as a second-line treatment for attention deficit hyperactivity disorder (ADHD).

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