TNF receptor associated factor

Tumor necrosis factor receptor-associated factors (TRAFs) are a family of proteins that function as signaling molecules and are primarily involved in the regulation of inflammation, antiviral responses, and apoptosis. They perform their roles by interacting with various receptors that share a TRAF-binding motif. Mutations and disruptions in signaling pathways downstream of their receptors can cause immune-mediated diseases and conditions related to acute inflammation.

Currently, seven TRAF proteins have been characterized in mammals: TRAF1, TRAF2, TRAF3, TRAF4, TRAF5, TRAF6, and .