Topic summary
4-Hydroxytryptamine
4-Hydroxytryptamine (4-HT, 4-HTA), also known as N,N-didesmethylpsilocin, is a naturally occurringtryptaminealkaloid. It is closely related chemically to the neurotransmitterserotonin, the psychedelicpsilocin, and is the active form of the tryptamine alkaloid norbaeocystin.
The compound is a serotonin receptor agonist, including of the serotonin 5-HT2A receptor, but in contrast to certain closely related compounds like psilocin, appears to be non-hallucinogenic.
4-HT may occur naturally in Psilocybe baeocystis and Psilocybe cyanescens. It may serve as an alternative precursor in the biosynthesis of psilocybin (4-PO-DMT) in psilocybin mushrooms.