Topic summary
Stopping rule
Extracted from the Wikipedia article Stopping time.
Stopping rules in clinical trials
Clinical trials in medicine often perform interim analysis, in order to determine whether the trial has already met its endpoints. However, interim analysis create the risk of false-positive results, and therefore stopping boundaries are used to determine the number and timing of interim analysis (also known as alpha-spending, to denote the rate of false positives). At each of R interim tests, the trial is stopped if the likelihood is below a threshold p, which depends on the method used. See Sequential analysis.