Topic summary
Steroid injections
Extracted from the Wikipedia article Corticosteroid.
References
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Rarely, corticosteroids have been abused for their euphoria-producing effects, producing drug dependency.31–33
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CORTICOSTEROID ABUSE: Several case reports describe corticosteroid abuse or dependence driven by the euphoria these medications can induce. These cases typically involve high-dose oral or intravenous formulations, but at least 1 case of dexamethasone nasal spray abuse has been reported.33 Most cases of corticosteroid abuse have been described in patients with a premorbid history of either psychiatric illness or drug or alcohol dependence.34
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Glucocorticoids can also have mood-elevating effects, whose loss might fit better into a model of GR-impaired depression (392). Such effects are manifested in psychiatrically normal subjects as euphoria after exogenous administration, as depression after steroid withdrawal, and in a few cases, as steroid abuse (50, 210, 394). Mood improvements after glucocorticoid treatment occur before significant amelioration of the diseases for which the steroids were prescribed (373, 394), making it unlikely that euphoric effects were due to relief of disease symptoms. [...]
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