SH2 domain

The SH2 (Src Homology 2) domain is a structurally conserved protein domain contained within the Srconcoprotein and in many other intracellular signal-transducing proteins. SH2 domains bind to phosphorylatedtyrosine residues on other proteins, modifying the function or activity of the SH2-containing protein. The SH2 domain may be considered as a prototypical modular protein-protein interaction domain, in that it allows for the transmission of signals controlling a variety of intracellular functions. SH2 domains are especially common in adaptor proteins that aid in the signal transduction of receptor tyrosine kinase pathways.