Topic summary
Nucleophilic attack
Extracted from the Wikipedia article Nucleophile.
Swain–Scott equation
This free-energy relationship relates the pseudo first orderreaction rate constant (in water at 25 °C), k, of a reaction, normalized to the reaction rate, k0, of a standard reaction with water as the nucleophile, to a nucleophilic constant n for a given nucleophile and a substrate constant s that depends on the sensitivity of a substrate to nucleophilic attack (defined as 1 for methyl bromide).