Neuropeptide FF

More reference expression dataBioGPSEnsemblUniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)Chr 12: 53.51 – 53.51 MbChr 15: 102.43 – 102.43 MbPubMed searchWikidata

Neuropeptide FF (NPFF, FLFQPQRFa) is a mammalian amidated neuropeptide originally isolated from bovine brain and characterized as a pain-modulating peptide, with anti-opioid activity on morphine-induced analgesia.

In humans, neuropeptide FF peptides are encoded by the NPFFgene. Two genes encoding two different receptors (NPFF1 and NPFF2) and two precursors [NPFFA (this gene) and NPFFB (NPVF)] have been cloned in several mammalian species.