Topic summary
Neurofibrillary tangles
Extracted from the Wikipedia article Neurofibrillary tangle.
Neurofibrillary tangles (NFTs) are intracellular aggregates of hyperphosphorylatedtau protein that are most commonly known as a primary biomarker of Alzheimer's disease. NFTs also are present in numerous other diseases known collectively as tauopathies. Little is known about their exact relationship to the different pathologies, but it is typically recognized that tauopathy is an important factor in the pathogenesis of several neurodegenerative diseases.