List of presidents of the United States who died in office

Since the office was established in 1789, 45 individuals have served as president of the United States. Of these, eight have died in office, of whom four were assassinated and four died of natural causes. In each of these instances, the vice president has succeeded to the presidency. This practice is now governed by Section One of the Twenty-fifth Amendment to the United States Constitution, ratified in 1967, which declares that, "the Vice President shall become President" if the president is removed from office, dies, or resigns. The initial authorization for this practice was provided by Article II, Section 1, Clause 6, of the U.S. Constitution.

The first incumbent U.S. president to die was William Henry Harrison, on April 4, 1841, only one month after Inauguration Day. He died from complications of what at the time was believed to be pneumonia. The second U.S. president to die in office, Zachary Taylor, died on July 9, 1850, from acute gastroenteritis. Abraham Lincoln was the third U.S. president to die in office, and was the first to be assassinated. He was shot by John Wilkes Booth on the night of April 14, 1865, and died the following morning. Sixteen years later, on July 2, 1881, James A. Garfieldwas shot by Charles J. Guiteau, surviving for 79 days before dying on September 19, 1881.

On September 14, 1901, William McKinley died, eight days after being shot by Leon Czolgosz. Next, Warren G. Harding suffered a heart attack, and died on August 2, 1923. On April 12, 1945, Franklin D. Roosevelt (who had just begun his fourth term in office) collapsed and died as a result of a cerebral hemorrhage. The most recent U.S. president to die in office was John F. Kennedy, who was shot by Lee Harvey Oswald on November 22, 1963, in Dallas, Texas.