Heterocyclic compounds

Uses

Heterocyclic compounds are pervasive in many areas of life sciences and technology. Many drugs are heterocyclic compounds. Among the modifications to the family of antitumor compounds, heterocyclic organic compounds have been extensively applied by many groups in order to modify the reactivity profile. Pyrrole, pyrimidine, indole, quinoline and purine are few classes of heterocycles which showed interesting cytotoxicity profiles, which can be highly beneficial when developing cancer drugs. Heterocyclic compounds play a central role in modern medicinal chemistry, with a large majority of newly approved drugs, containing at least one heterocyclic ring particularly nitrogen-containing systems. Their prevalence is attributed to their ability to modulate physicochemical properties such as solubility, lipophilicity, and binding affinity to biological targets.