GABA reuptake inhibitor

A GABA reuptake inhibitor (GRI), also known as a GABA transporter blocker, is a type of drug which acts as a reuptake inhibitor of the major inhibitoryneurotransmitterγ-aminobutyric acid (GABA) by blocking the action of one or more of the GABA transporters (GATs), such as the GABA transporter 1 (GAT-1). This in turn leads to increased extracellularconcentrations of GABA and an increase in GABAergicneurotransmission.