Topic summary
Fusion peptide
Extracted from the Wikipedia article Membrane fusion protein.
Class I
Class I fusion proteins resemble influenzavirushemagglutinin in their structure. Post-fusion, the active site has a trimer of α-helical coiled-coils. The binding domain is rich in α-helices and hydrophobic fusion peptides located near the N-terminus (some examples show internal fusion peptides, however). Fusion conformation change can often be controlled by pH.