Topic summary
2,5-Dimethoxy-4-bromoamphetamine
2,5-Dimethoxy-4-bromoamphetamine (DOB), also known as brolamfetamine (INN), is a psychedelic drug of the phenethylamine, amphetamine, and DOx families. For many years, prior to the discovery of newer compounds, DOB was the most potent known phenethylamine psychedelic. It is taken orally.
The drug acts as an agonist of the serotonin5-HT2 receptors, including of the serotonin 5-HT2A receptor. Analogues of DOB include 2C-B, DOM, DOI, and Bromo-DragonFLY (DOB-DFLY), among others.
DOB was first synthesized by Alexander Shulgin in 1967 and was described by him and his colleagues in the scientific literature in 1971. Shulgin subsequently further described the effects of DOB in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved).