DNA polymerase III holoenzyme

DNA polymerase III holoenzyme is the primary enzyme complex involved in prokaryoticDNA replication. It was discovered by Thomas Kornberg (son of Arthur Kornberg) and in 1970. The complex has high processivity (i.e. the number of nucleotides added per binding event) and, specifically referring to the replication of the E. coligenome, works in conjunction with four other DNA polymerases (Pol I, Pol II, Pol IV, and Pol V). Being the primary holoenzyme involved in replication activity, the DNA Pol III holoenzyme also has proofreading capabilities that corrects replication mistakes by means of exonuclease activity reading 3'→5' and synthesizing 5'→3'. DNA Pol III is a component of the replisome, which is located at the replication fork.