Topic summary
D2 receptor
Extracted from the Wikipedia article Dopamine receptor D2.
Dopamine receptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2gene. After work from Paul Greengard's lab had suggested that dopamine receptors were the site of action of antipsychotic drugs, several groups, including those of Solomon H. Snyder and Philip Seeman used a radiolabeled antipsychotic drug to identify what is now known as the dopamine D2 receptor. The dopamine D2 receptor is the main receptor for most antipsychotic drugs. The structure of DRD2 in complex with the atypical antipsychotic risperidone has been determined.