Cheyenne Depot Museum

Union Pacific Railroad Depot
Union Pacific Roundhouse, Turntable and Machine Shop

U.S. National Register of Historic Places

Union Pacific Passenger Station

Location121 W. 15th St., Cheyenne, WyomingCoordinates41°7′54″N104°48′51″W / 41.13167°N 104.81417°WBuilt1887ArchitectVan Brunt & HoweArchitectural styleRomanesque Revival, Richardsonian RomanesqueNRHP reference No.73001934 (depot);
92000930Significant datesAdded to NRHPJanuary 29, 1973 (depot);
July 24, 1992Designated NHLFebruary 15, 2006 (depot)

The Cheyenne Depot Museum is a railroad museum in Cheyenne, Wyoming, United States. It is located inside the 1880s Union Pacific Railroad depot. A National Historic Landmark, the station was the railroad's largest west of Council Bluffs, Iowa, and a major western example of Richardsonian Romanesque architecture.

The museum, founded in 1993, interprets Cheyenne's early history and that of the construction of the Union Pacific Railroad. It houses multiple exhibits and occasionally offers tours of other railroad facilities.