Catecholaminergic activity enhancer

References

1. ^ . Progress in Neuro-Psychopharmacology and Biological Psychiatry. 28 (3): 421–427. doi:10.1016/j.pnpbp.2003.11.016. ISSN 0278-5846. PMID 15093948. S2CID 37564231.
2. ^ 19. doi:10.2174/157488707779318107. PMID 18473983. In addition, the compounds previously described by Knoll and colleagues [33, 34], along with a series of trace amine derivatives synthesized by Ling et al. [35] are potential TAAR ligands. Although neither of these classes of compound appear to have been examined for efficacy at TAAR, their strong structural similarity to trace amines suggests that such studies are warranted.
3. ^ . PMC 9369307. PMID 35955676.
4. ^ . PMC 10487936. PMID 37686140.
5. ^ 45. doi:10.1111/j.1527-3458.2001.tb00202.x. PMC 6494119. PMID 11607046.
6. ^ . Phytomedicine. 55: 148–164. doi:10.1016/j.phymed.2018.07.010. ISSN 0944-7113. PMID 30668425. S2CID 58948967.
7. ^ 94. doi:10.1007/3-540-27434-0_4. ISBN .
8. ^ 197. doi:10.1016/j.pbb.2008.03.016. PMID 18456311.
9. ^ 1297. doi:10.1023/a:1024224311289. PMID 12834268.
10. ^ 84. doi:10.1016/s0024-3205(02)01968-9. PMID 12175892.
11. ^ . PMID 42449077.
12. ^ 2114. doi:10.1016/0024-3205(96)00204-4. PMID 8649195.
13. ^ 1503. doi:10.1038/mp.2016.127. ISSN 1476-5578. PMID 27480491. S2CID 205202709.
14. ^ 14. doi:10.1016/j.pnpbp.2005.06.004. PMID 16023777.
15. ^ 1732. doi:10.1038/sj.bjp.0702995. PMC 1571822. PMID 10588928.
16. ^ 73. doi:10.1007/978-3-7091-7494-4_6. ISBN . PMID 8988462.
17. ^ 60. PMID 3083795.
18. ^ 714. doi:10.1016/0091-3057(93)90566-c. PMID 8278449.
19. ^ 587. doi:10.1016/j.psym.2015.05.003. PMID 26198572.
20. ^ 1717. doi:10.1007/s00702-018-1932-y. PMID 30255284.
21. ^ 15. PMID 7893186.
22. ^ 458. doi:10.1016/j.pharep.2013.11.003. PMID 24905523.
23. ^ . Neuropsychopharmacol Hung (in Hungarian). 10 (1): 15–22. PMID 18771016.
24. ^ 66. doi:10.1111/j.1600-0773.1998.tb01399.x. PMID 9498233.
25. ^ 29. ISSN 0003-9780. PMID 1356324.
26. ^ 53. doi:10.1002/cbf.1183. PMID 15584092. S2CID 11027835.
27. ^ 212. doi:10.1016/s0968-0896(01)00002-5. PMID 11377178.
28. ^ 161. doi:10.1007/BF03190451. ISSN 2107-0180. PMID 12365195. S2CID 30618267.
29. ^ 176. doi:10.1111/j.1471-4159.2010.07109.x. PMC 3005101. PMID 21073468.
30. ^ . J Pharmacol Exp Ther. 357 (1): 134–144. doi:10.1124/jpet.115.229765. PMID 26791601. Archived from the original(PDF) on 9 May 2025.
31. ^ . PMID 39903411.
32. ^ 1932. doi:10.1007/s11064-010-0238-8. PMID 20725780.
33. ^
34. ^ 401. doi:10.1016/bs.apha.2021.10.005. ISBN . PMC 9826737. PMID 35341572. It is reported that methamphetamine (METH) interacts with TAAR1 and subsequently inhibits DA uptake, enhance DA efflux and induces DAT internalization, and these effects are dependent on TAAR1 (Xie & Miller, 2009). For example, METH-induced inhibition of DA uptake was observed in TAAR1 and DAT cotransfected cells and WT mouse and monkey striatal synaptosomes but not in DAT-only transfected cells or in striatal synaptosomes of TAAR1-KO mice (Xie & Miller, 2009). TAAR1 activation was enhanced by co-expression of monoamine transporters and this effect could be blocked by monoamine transporter antagonists (Xie & Miller, 2007; Xie et al., 2007). Furthermore, DA activation of TAAR1 induced C-FOS-luciferase expression only in the presence of DAT (Xie et al., 2007).
35. ^ 325. doi:10.1124/jpet.109.153775. PMC 2700171. PMID 19364908.
36. ^ 7048. doi:10.1016/j.bmc.2011.10.007. PMC 3236098. PMID 22037049. While our data suggest a role for TAAR1 in eliciting amphetamine-like stimulant effects, it must be borne in mind that the observed in vivo effects are likely to result from interaction with both TAAR1 and monoamine transporters. Thus it has been shown that the selective TAAR1 agonist RO5166017 fully prevented psychostimulant-induced and persistent hyperdopaminergia-related hyperactivity in mice.42 This effect was found to be DAT-independent, since suppression of hyperactivity was observed in DAT-KO mice.42 The collected information leads us to conclude that TAAR1 is a stereoselective binding site for amphetamine and that TAAR1 activation by amphetamine and its congeners may contribute to the stimulant properties of this class of compounds.
37. ^ 238. doi:10.1007/s10571-020-00792-8. PMC 7845786. PMID 31974906.
38. ^ 194. doi:10.1007/7355_2014_78. ISBN .
39. ^ 956. doi:10.1124/jpet.107.132647. PMID 18083911.
40. ^ 207. doi:10.1016/j.pbb.2011.10.025. PMC 3288391. PMID 22079347.
41. ^
42. ^ 164. doi:10.1007/164_2018_113. ISBN . PMID 29633178. The activation of human TAAR1 might diminish the effects of psychostimulation and intoxication arising from 7-APB effects on monoamine transporters (see 4.1.3. for more details). Affinity to mouse and rat TAAR1 has been shown for many psychostimulants, but species differences are common (Simmler et al. 2016). For example, [5-(2-aminopropyl)indole (5-IT)] and [4-methylamphetamine (4-MA)] bind and activate TAAR1 in the nanomolar range, but do not activate human TAAR1.{{}}: CS1 maint: periodical has ISBN ()
43. ^ 100. Bibcode:2019NeuTx..72...95R. doi:10.1016/j.neuro.2019.02.011. PMID 30776375.
44. ^ 496. doi:10.1177/0269881113482532. PMC 3666194. PMID 23539642.
45. ^{{}}: CS1 maint: deprecated archival service ()
46. ^ 189. doi:10.1016/s0014-2999(01)01040-8. PMID 11516435.
47. ^ 587. doi:10.1016/s0031-9384(96)80035-7. PMID 8840922.
48. ^ 134. PMID 2115226.
49. ^ 110. doi:10.4324/9781003058892-3. ISBN .
50. ^ 2024.
51. ^
52. ^ 620. doi:10.1016/0024-3205(94)00494-d. PMID 7869839.
53. ^ 2930. doi:10.1016/s0024-3205(03)00192-9. PMID 12697275.
54. ^ 773. doi:10.1016/s0024-3205(00)00671-8. PMID 10968406.
55. ^ 72. doi:10.1111/j.1600-0773.1994.tb00326.x. PMID 7971740.
56. ^ 1057. doi:10.1016/0024-3205(94)00415-3. PMID 8152326.
57. ^ 2024.
58. ^ 1927. doi:10.1111/bcp.13651. PMC 6089809. PMID 29847694.
59. ^ 220. PMID 15825677.
60. ^ 161. doi:10.1007/BF03190451. PMID 12365195.