Topic summary
Bowen's Disease
Extracted from the Wikipedia article Cutaneous squamous-cell carcinoma.
In situ disease
Bowen's disease (also known as cSCC in situ) is SCC that has not invaded through the basement membrane and is localized to the top layer of skin (the epidermis). The risk of progression of SCC in situ to cSCC is 3-5%, and if progression does occur, the risk of metastasis is 20%. The skin cells are often highly atypical under the microscope, and may look more unusual than the cells of some invasive squamous-cell carcinomas.