Angiotensin-converting enzyme

More reference expression dataBioGPSEnsemblUniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)Chr 17: 63.48 – 63.5 MbChr 11: 105.86 – 105.88 MbPubMed searchWikidata

Angiotensin-converting enzyme (EC3.4.15.1), or ACE, is a central component of the renin–angiotensin system (RAS), which controls blood pressure by regulating the volume of fluids in the body. It converts the hormone angiotensin I to the active vasoconstrictorangiotensin II. Therefore, ACE indirectly increases blood pressure by causing blood vessels to constrict. ACE inhibitors are widely used as pharmaceutical drugs for treatment of cardiovascular diseases.

Other lesser known functions of ACE are degradation of bradykinin, substance P and amyloid beta-protein.