5-HT7 receptor

More reference expression dataBioGPSEnsemblUniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)Chr 10: 90.74 – 90.86 MbChr 19: 35.94 – 36.03 MbPubMed searchWikidata

The 5-HT₇ receptor is a member of the GPCR superfamily of cell surface receptors and is activated by the neurotransmitterserotonin (5-hydroxytryptamine, 5-HT). The 5-HT₇ receptor is coupled to G_s (stimulates the production of the intracellular signaling molecule cAMP) and is expressed in a variety of human tissues, particularly in the brain, the gastrointestinal tract, and in various blood vessels. This receptor has been a drug development target for the treatment of several clinical disorders. The 5-HT₇ receptor is encoded by the HTR7gene, which in humans is transcribed into 3 different splice variants.