3-dehydroquinate synthase II

3-dehydroquinate synthase II (EC 1.4.1.24, DHQ synthase II, MJ1249 (gene), aroB' (gene)) is an enzyme with systematic name2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate:NAD oxidoreductase (deaminating). This enzyme catalyses the following chemical reaction

(1)

+ NAD

H₂O

H

Reversible left-right reaction arrow with minor forward substrate(s) from top left, minor forward product(s) to top right, minor reverse substrate(s) from bottom right and minor reverse product(s) to bottom left

H₂O

H

3-Dehydroquinic acid

+ NADH + NH₃

The three substrates of this enzyme are 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonic acid (1), water, and oxidised nicotinamide adenine dinucleotide (NAD). Its products are 3-dehydroquinic acid, ammonia, reduced NADH, and a proton. It was isolated from the archaeonMethanocaldococcus jannaschii.