2022 NCAA Division I women's basketball tournament

The 2022 NCAA Division I women's basketball tournament was a single-elimination tournament of 68 teams to determine the National Collegiate Athletic Association (NCAA) Division Icollege basketball national champion for the 2021–22 NCAA Division I women's basketball season. The 40th edition of the tournament began on March 16, 2022, and concluded with the championship game on April 3 at Target Center in Minneapolis, where the South Carolina Gamecocks defeated the UConn Huskies 64–49 to win their second NCAA title, and handing UConn its first loss in the championship game. This tournament marked the introduction of the "First Four" round and an expansion of the field of participants from 64 teams to 68, mirroring the men's tournament since 2011.

Big South champion Longwood, Horizon champion IUPUI and Southland champion Incarnate Word made their tournament debuts. Tennessee continued its record streak of making , while UConn extended its record streak of 14 consecutive Final Four appearances.