2010 National League Division Series

DatesOctober 6–10TelevisionTBSTV announcersBrian Anderson and Joe SimpsonRadioESPNRadio announcersJon Sciambi and Dave CampbellUmpiresJohn Hirschbeck, Bruce Dreckman, Sam Holbrook, Ed Rapuano, Gary Cederstrom and Rob DrakeTeamsDatesOctober 7–11TelevisionTBSTV announcersDick Stockton and Bob BrenlyRadioESPNRadio announcersChris Berman (in San Francisco)
Dave O'Brien (in Atlanta) and Rick SutcliffeUmpiresDana DeMuth, Paul Nauert, Paul Emmel, Mike Winters, Jerry Layne and Ed Hickox

The 2010 National League Division Series (NLDS) were two opening round best-of-five-game series in Major League Baseball’s 2010 postseason to determine the participating teams in the 2010 National League Championship Series. The three divisional winners and a fourth team—a "Wild Card"—played in two series from October 6 to 11. TBS televised all games in the United States.

Under MLB's playoff format, no two teams from the same division were matched up in the Division Series, regardless of whether their records would normally indicate such a matchup. Home field advantage went to the team with the better regular-season record with the exception of the wild card team, which defers home field advantage regardless of record. The matchups were:

• (1) Philadelphia Phillies (Eastern Division champions, 97–65) vs. (3) Cincinnati Reds (Central Division champions, 91–71): Phillies win series, 3–0.
• (2) San Francisco Giants (West Division champions, 92–70) vs. (4) Atlanta Braves (Wild Card qualifier, 91–71): Giants win series, 3–1.

The Phillies and Reds had met in the postseason once before: in the 1976 NLCS, which the Reds won 3–0. The Giants and Braves also had one prior postseason series—the 2002 NLDS—which the Giants won 3–2.

The Giants would go on to defeat the Phillies in the NLCS, then win the 2010 World Series by defeating the American League champion Texas Rangers, winning their first World title since 1954.