2010 Mutua Madrileña Madrid Open – Men's singles

Rafael Nadal defeated defending champion Roger Federer in a rematch of the previous year's final, 6–4, 7–6 to win the men's singles tennis title at the 2010 Madrid Open. It was his second Madrid Open title and 18th Masters 1000 title overall, surpassing Andre Agassi's record (since the series started in 1990). It also marked the third leg of Nadal’s Clay Slam: a season sweep of the Monte-Carlo, Rome, Madrid, and French Openclay court tournaments.

This tournament marked the final professional appearance of former world No. 1, 1998 French Open and three-time Masters champion Carlos Moyá; he lost in the first round to Benjamin Becker.