2007 US Open – Women's singles

Justine Henin defeated Svetlana Kuznetsova in the final, 6–1, 6–3 to win the women's singles tennis title at the 2007 US Open. It was her second US Open and seventh and last major title overall. Henin did not lose a set during the tournament. It was her last US Open appearance.

Maria Sharapova was the defending champion, but was defeated by Agnieszka Radwańska in the third round.

This tournament marked the final major singles appearance of former world No. 1 and five-time major singles champion Martina Hingis, who retired in November 2007 (she would later return to the sport in doubles starting in 2013). She was beaten in the third round by Victoria Azarenka. It was also the first US Open main draw appearance for future world No. 1s Caroline Wozniacki and also future champion Angelique Kerber; they lost in the first and second rounds to Serena Williams and Alizé Cornet, respectively.