2005 Mutua Madrileña Masters Madrid – Singles

Rafael Nadal defeated Ivan Ljubičić in the final, 3–6, 2–6, 6–3, 6–4, 7–6 to win the singles tennis title at the 2005 Madrid Open. This would remain his sole indoor hardcourt title for the entirety of his career.

Marat Safin was the reigning champion, but chose not to compete.