1991 Australian Open – Women's singles

Monica Seles defeated Jana Novotná in the final, 5–7, 6–3, 6–1 to win the women's singles tennis title at the 1991 Australian Open. It was her first Australian Open title and second major title overall. Seles saved a match point en route to the title, in the semifinals against Mary Joe Fernández. Seles was making her tournament debut.

Steffi Graf was the three-time defending champion, but lost to Novotná in the quarterfinals.