1981 Wimbledon Championships – Women's singles

Chris Evert Lloyd defeated Hana Mandlíková in the final, 6–2, 6–2 to win the ladies' singles tennis title at the 1981 Wimbledon Championships. It was her third Wimbledon singles title and twelfth major singles title overall, surpassing Margaret Court's Open Era record. Evert did not lose a set during the tournament.

Evonne Goolagong Cawley was the reigning champion, but did not compete due to pregnancy.

For only the second time in the history of the championships and for the first time since 1965, no British player was seeded in the women's singles championship.