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Subcellular localization

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The cells of eukaryotic organisms are elaborately subdivided into functionally-distinct membrane-bound compartments. Some major constituents of eukaryotic cells are: extracellular space, plasma membrane, cytoplasm, nucleus, mitochondria, Golgi apparatus, endoplasmic reticulum (ER), peroxisome, vacuoles, cytoskeleton, nucleoplasm, nucleolus, nuclear matrix and ribosomes. Bacteria also have subcellular localizations that can be separated when the cell is fractionated.

Cell membraneCell membraneThe cell membrane (also known as the plasma membrane or cytoplasmic membrane, and historically referred to as the plasmalemma) is a semipermeablebiological membrane that separates and protects the interior of a cell from the outside environment (the extracellular space).CytoplasmCytoplasmThe cytoplasm is all the material within a eukaryotic or prokaryoticcell, enclosed by the cell membrane, including the organelles and excluding the nucleus in eukaryotic cells. The material inside the nucleus of a eukaryotic cell and contained within the nuclear membrane is termed the nucleoplasm. The main components of the cytoplasm are the cytosol (a gel-like substance), the cell's internal sub-structures, and various cytoplasmic inclusions.Extracellular spaceExtracellular space refers to the part of a multicellular organism outside the cells, usually taken to be outside the plasma membranes, and occupied by fluid. This is distinguished from intracellular space, which is inside the cells. The composition of the extracellular space includes metabolites, ions, proteins, and many other substances that might affect cellular function.MitochondriaMitochondriaOrganelle in eukaryotic cells responsible for respirationA mitochondrion (pl. mitochondria) is an organelle found in the cells of most eukaryotes, such as animals, plants and fungi. Mitochondria have a double membrane structure and use aerobic respiration to generate adenosine triphosphate (ATP), which is used throughout the cell as a source of chemical energy. They were discovered by Albert von Kölliker in 1857 in the voluntary muscles of insects.VacuoleVacuoleA vacuole () is a membrane-bound organelle which is present in plant and fungalcells and some protist, animal, and bacterial cells. Vacuoles are essentially enclosed compartments which are filled with water containing inorganic and organic molecules including enzymes in solution, though in certain cases they may contain solids which have been engulfed. Vacuoles are formed by the fusion of multiple membrane vesicles and are effectively just larger forms of these.Cell (biology)Cell (biology)Basic unit of life formsThe cell is the basic structural and functional unit of all forms of life or organisms. The term comes from the Latin word cellula meaning 'small room'. A biological cell basically consists of a semipermeablecell membrane enclosing cytoplasm that contains genetic material. Most cells are only visible under a microscope.CytoskeletonCytoskeletonThe cytoskeleton is a complex, dynamic network of interlinking protein filaments present in the cytoplasm of all cells, including those of bacteria and archaea. In eukaryotes, it extends from the cell nucleus to the cell membrane and is composed of similar proteins in the various organisms.Cell nucleusCell nucleusOrganelle in eukaryotic cellsHeLa cells stained for nuclear DNA with the blue fluorescentHoechst dye. The central and rightmost cells are in interphase, thus their entire nuclei are labeled. On the left, a cell is going through mitosis and its DNA has condensed.The cell nucleus (from Latin nucleus or nuculeus 'kernel, seed'; pl.: nuclei) is a membrane-bound organelle found in eukaryotic cells.Golgi apparatusGolgi apparatusThe Golgi apparatus (), also known as the Golgi complex, Golgi body, or simply the Golgi, is an organelle found in most eukaryoticcells. Part of the endomembrane system in the cytoplasm, it packages proteins into membrane-boundvesicles inside the cell before the vesicles are sent to their destination. It resides at the intersection of the secretory, lysosomal, and endocytic pathways.EukaryoteEukaryoteDomain of life whose cells have nucleiThe eukaryotes () are cellularorganisms of the domainEukaryota or Eukarya, which have a distinct cell nucleus (formed by a nuclear membrane), membrane-bound organelles and organization supported by a cytoskeleton. Extant eukaryotes are traditionally grouped into four kingdoms: animals, plants, fungi and protists.Endoplasmic reticulumEndoplasmic reticulumThe endoplasmic reticulum (ER) is a part of a transportation system of the eukaryotic cell, and has many other important functions such as protein folding. The word endoplasmic means "within the cytoplasm", and reticulum is Latin for "little net". It is a type of organelle made up of two subunits – rough endoplasmic reticulum (RER), and smooth endoplasmic reticulum (SER).PeroxisomePeroxisomeA peroxisome () is a membrane-bound organelle, a type of microbody, found in the cytoplasm of virtually all eukaryotic cells. Peroxisomes are oxidative organelles. Frequently, molecular oxygen serves as a co-substrate, from which hydrogen peroxide (H2O2) is then formed. Peroxisomes owe their name to hydrogen peroxide-generating and scavenging activities. They perform key roles in lipid metabolism and the reduction of reactive oxygen species.

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