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Perinatal asphyxia

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Perinatal asphyxia (also known as neonatal asphyxia or birth asphyxia) is the medical condition resulting from deprivation of oxygen to a newborn infant that lasts long enough during the birth process to cause physical harm, usually to the brain. It remains a serious condition which causes significant mortality and morbidity. It is also the inability to establish and sustain adequate or spontaneous respiration upon delivery of the newborn, an emergency condition that requires adequate and quick measures.

AsphyxiaAsphyxiaSeverely deficient supply of oxygenMedical conditionAsphyxia or asphyxiation is a condition of deficient supply of oxygen to the body which arises from abnormal breathing. Asphyxia causes generalized hypoxia, which affects all the tissues and organs, some more rapidly than others. There are many circumstances that can induce asphyxia, all of which are characterized by the inability of a person to acquire sufficient oxygen through breathing for an extended period of time.ChildbirthChildbirthConclusion of the human pregnancyMedical conditionChildbirth, also known as labour or delivery, is the completion of pregnancy, where one or more fetuses exits the internal environment of the mother vaginally or via caesarean section and becomes a newborn. In 2023, there were about 132 million human births globally. In developed countries, most births occur in hospitals, while in developing countries most are home births.PerfusionPerfusionPerfusion is the passage of fluid through the circulatory system or lymphatic system to an organ or a tissue, usually referring to the delivery of blood to a capillary bed in tissue. Perfusion may also refer to fixation via perfusion, used in histological studies. Perfusion is measured as the rate at which blood is delivered to tissue, or volume of blood per unit time (blood flow) per unit tissue mass.BreathingBreathingBreathing (respiring or ventilating) is the rhythmic process of inhaling air into the lungs providing oxygen, and exhaling the air removing carbon dioxide, in the gas exchange process. All aerobic organisms require oxygen for cellular respiration, which extracts energy from food and produces carbon dioxide as a waste product.Metabolic acidosisMetabolic acidosisMetabolic acidosis is a serious electrolyte disorder characterized by an imbalance in the body's acid-base balance. Metabolic acidosis has three main root causes: increased acid production, loss of bicarbonate, and a reduced ability of the kidneys to excrete excess acids. Metabolic acidosis can lead to acidemia, which is defined as arterial blood pH that is lower than 7.35.FetusFetusA fetus or foetus (; pl.: fetuses or foetuses) is the unborn offspring of a viviparousanimal that develops from an embryo. Following the embryonic stage, the fetal stage of development takes place. Prenatal development is a continuum, with no clear defining feature distinguishing an embryo from a fetus.ResuscitationResuscitationResuscitation is the process of correcting physiological disorders (such as lack of breathing or heartbeat) in an acutely ill patient. It is an important part of intensive care medicine, anesthesiology, trauma surgery and emergency medicine. Well-known examples are and . Adequate resuscitation and end-organ perfusion is best indicated by urine output of 0.5-1 mL/kg/h. For the average adult male weighing ~70 kg this would mean a urine output of 35 mL/h (70 x 0.5 = 35 mL/h).Insult (medical)Insult (medical)In medical terms, an insult is the cause of some kind of physical or mental injury. For example, a burn on the skin (the injury) may be the result of a thermal, chemical, radioactive, or electrical event (the insult). Likewise, sepsis and trauma are examples of foreign insults, and encephalitis, multiple sclerosis, and brain tumors are examples of insults to the brain. Clinicians may use the term cerebrovascular insult (CVI) as a synonym for a stroke.GestationGestationGestation is the period of development during the carrying of an embryo, and later fetus, inside viviparous animals (the embryo develops within the parent). It is typical for mammals, but also occurs for some non-mammals. Mammals during pregnancy can have one or more gestations at the same time, for example in a multiple birth. The time interval of a gestation is called the gestation period.WhoWhoLook up or in Wiktionary, the free dictionary.Acid–base homeostasisAcid–base homeostasisAcid–base homeostasis is the homeostatic regulation of the pH of the body'sextracellular fluid (ECF). The proper balance between the acids and bases (i.e. the pH) in the ECF is crucial for the normal physiology of the body—and for cellularmetabolism. The pH of the intracellular fluid and the extracellular fluid need to be maintained at a constant level.DiseaseDiseaseA disease is a particular abnormal condition that adversely affects the structure or function of all or part of an organism and is not immediately due to any external injury. Diseases are often known to be medical conditions that are associated with specific signs and symptoms. A disease may be caused by external factors such as pathogens or by internal dysfunctions.

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