PLOS Computational Biology is a monthly peer-reviewed open access scientific journal covering computational biology. It was established in 2005 by the Public Library of Science in association with the International Society for Computational Biology (ISCB) in the same format as the previously established PLOS Biology and PLOS Medicine. The founding editor-in-chief was Philip Bourne. The current editors-in-chief are Feilim Mac Gabhann and Virginia E. Pitzer.
